Table 1.

Selection of proteins identified only in metastasis, only in liver, or in both types of tissue specimens

Accession numberProtein nameLiver (total = 6) *Metastasis (total = 8) *
Q8R0Y610-Formyltetrahydrofolate dehydrogenase50
P494294-hydroxyphenylpyruvate dioxygenase50
Q61176Arginase 150
P16015Carbonic anhydrase III50
Q9WVT6Carbonic anhydrase XIV50
P24270Catalase50
P00186Cytochrome P450 1A250
Q8VCW9Cytochrome P450, family 2, subfamily a, polypeptide 1250
Q64374Regucalcin50
Q6XL44UDP glycosyltransferase 1 family polypeptide50
Q62452UDP-glucuronosyltransferase 1-750
P25688Uricase50
Q91W31Transmembrane protein TIARP40
P34927Asialoglycoprotein receptor 130
P70694Estradiol 17β-dehydrogenase 554
P24549Retinal dehydrogenase 154
Q9QXZ6Solute carrier organic anion transporter57
P11087Collagen α1(I) chain58
Q921I1Serotransferrin58
Q63880Liver carboxylesterase 3141
Q9JJL3Solute carrier organic anion transporter family member 1B243
Q01279Epidermal growth factor receptor46
P11276 Fibronectin48
Q99K47Fibrinogen, α polypeptide28
O88322Nidogen-217
Q8K0E8Fibrinogen β chain18
Q05793Perlecan18
Q61838α-2-Macroglobulin08
Q80X19Collagen α 1(XIV) chain08
P28665Murinoglobulin-108
Q06890Clusterin07
Q60849CD98 heavy chain06
P29788Vitronectin05
O08677Kininogen-104
P20918Plasminogen04
Q61247α-2-Antiplasmin03
Q01339β-2-Glycoprotein I03
P28653Biglycan03
P21995Embigin03
P02468Laminin γ-1 chain02
Q8BKG3Tyrosine-protein kinase-like 702
Q8K100Endoglin01
  • * Numbers indicate in how many of the six healthy in vivo biotinylated mice or the eight metastases-bearing in vivo biotinylated mice the protein was identified in the corresponding tissue samples. See Supplementary Table S1 for a list of all identified proteins in these in vivo biotinylated samples and additional negative control samples from unperfused mice.

  • The results for fibronectin precursor P11276 include also peptides that were originally assigned by the Mascot software to the fibronectin database entries Q3UHL6 and Q3TCF1 but also match with the entry P11276.