Table 3.

Functions associated with the top 10 networks for genes whose translation state was affected by radiation in cancer and normal cell lines

ScoreFocus moleculesTop functions
Cancer
    13735Cancer, cell cycle, skeletal and muscular disorders
    23534Connective tissue development and function, tissue development, amino acid metabolism
    33534Cell cycle, cell signaling, DNA replication, recombination, and repair
    43534RNA posttranscriptional modification, cell signaling, carbohydrate metabolism
    53534RNA posttranscriptional modification, cell death, connective tissue development and function
    63233Cellular assembly and organization, gene expression, cell cycle
    73233Cancer, hematologic disease, gastrointestinal disease
    83032Cell death, posttranslational modification, cancer
    93032Cancer, cellular movement, protein trafficking
    103032Cell signaling, DNA replication, recombination, and repair, gene expression
Normal
    13335Cell-to-cell signaling and interaction, tissue development, organismal development
    23034Cell cycle, cellular assembly and organization, DNA replication, recombination, and repair
    33034Cellular assembly and organization, cancer, cell cycle
    43034RNA posttranscriptional modification, gene expression, cellular assembly and organization
    53034Amino acid metabolism, posttranslational modification, small molecule biochemistry
    63034Hematologic disease, gene expression, lipid metabolism
    73034Inflammatory disease, immune response, cellular development
    83034Gene expression, cell signaling, lipid metabolism
    93034DNA replication, recombination, and repair, cell cycle, cancer
    102833Cell cycle, embryonic development, cellular assembly and organization
  • NOTE: Genes whose translation was affected by radiation in normal or cancer cell lines as defined by SAM (<1% FDR) were subjected to IPA, the top 10 networks with their top 3 associated function categories are shown. Score refers to statistical significance (negative logarithm of the P value); focus molecules refers to the number of genes (out of a possible 35) in each network.