Table 1.

Summary of the mutation analyses within the FAT region of human DLC-1 in various tissues

In prostate (cDNA)NucleotideNormalBPHTumoraa
Missense mutation869 C > T002 of 28P290L
902 C > A001 of 28T301K
923 G > T003 of 28S308I
Nonsense mutation929 C > A001 of 28S310Stop
Polymorphism1060 G > A7 of 75 of 1012 of 28V354M
In colon (genomic)NucleotideNormalTumorAa
Missense mutation923 G > T01/37S308I
959 G > T01/37S320I
1013 AC > TA01/37Y338L
Nonsense mutation1016 T > A01/37L339Stop
Polymorphism1060 G > A2 of 86/37V354M