Table 1.

Secondary genetic changes of BRCA1 in BRCA1-mutated ovarian cancer treated with platinum

PatientInherited mutationSpecimenClinical platinum sensitivitySecondary genetic change
Paired specimens
    CS1185delAGPre-platinumSensitive
Post-platinumSensitiveNo
    CS4185delAGPre-platinumSensitive
Post-platinumSensitiveNo
    UW91185delAGPre-platinumSensitive
Post-platinumResistantYes (back mutation)
    CS14185delAGPre-platinumSensitive
Post-platinumResistantNo
    UW402594delCPre-platinumResistantYes (back mutation)
Post-platinumResistantYes (2606_2628del23)
    UW80185delAGPre-platinumSensitive
Post-platinumResistantYes (back mutation)
    UWF27185delAGPre-platinumSensitive
Post-platinumResistantYes (back mutation)
Nonpaired posttreatment specimens
    UW2083867G>T (E1250X)Post-platinumSensitiveNo
    UW3173171insTGAGAPost-platinumResistantNo