Table 1.

Clinical data for patients

Patient no.SourceBlast, %FABCytogeneticsStatus
A. Samples used for colony assays
1BM47RAEBT46,XX,del(5)(q13q33)[2],42-46,XX,-2,-3,del(4)(q25q31.2),del(5)(q13q33),-6,-7,der(7;15)(q10;q10),+8,-12,-18,+20,+2-5mar[cp18]Relapsed/refractory
2BM99UNKPseudodiploid metaphase 46,XY,-3,add(12)(p13),+mar[1],Diploid male karyotype 46,XY[29]Relapsed/refractory
3BM65M2Pseudodiploid clone 46,XX,t(6;9)(p23;q34)[19],Hyperdiploid metaphase 47,XX,t(6;9)(p23;q34),+16[1]New
4BM88M4Pseudodiploid clone 46,XY,inv(16)(p13.1q22)[20]New
5BM86M1Hypodiploid clone 45,XX,-7[15],Diploid female karyotype 46,XX[5]Relapsed
6BM83M142-44,Y,del(X)(p22.1),-3,add(4)(q35),-5,del(7)(q22q34),add(12)(p13),-17,der(18)del(18)(p11.2)del(18)(q21.1),add(21)(p11.1),+0-2mar[cp20]Relapsed
7BM84UNKPseudodiploid clone 46,XY,inv(5)(p15.1q13)[12],Metaphases exhibiting random numerical and structural changes[2],Diploid male karyotype 46,XY[6]Relapsed/refractory
B. Samples used for in vitro assays
1PB85M1Diploid female karyotype 46,XX[19New
2PB20RAEBTPseudodiploid clone 46,XX,-7,+mar[18],Metaphases exhibiting random changes involving chromosome 7[2]Primary/refractory during salvage
3PB90M4Two hypodiploid clones 45,XX,t(3;3)(q21;q26),-7[9],45,XX,inv(1)(p22q32),t(3;3)(q21;q26),-7[6]Relapsed/refractory
4PB100M1Pseudodiploid clone 46,XY,t(12;17)(p13;q24)[20]Relapsed/refractory
5PB81M4Hypodiploid clone 45,XY,-7[11],Diploid male karyotype 46,XY[9]New
6PB93M045,XX,del(1)(p13p31),-7,t(11;19)(q23;p13.3),del(12)(p13)[5],45,idem,add(6)(q27)[2],45,XX,t(1;3)(p36.1;p21),t(5;6)(q11.2;q11),-7,t(11;19)(q23;p13.3)[13]Relapsed/refractory
7BM96M1Diploid male karyotype 46,XY[20]New
8PB62M5BPseudodiploid clone 46,X,idic(X)(p11.2)[4],Pseudodiploid metaphase 46,XX,t(1;4)(q42;q23)[1],Diploid female karyotype 46,XX[15]New
9PB95M2Metaphases exhibiting random numerical and structural changes[4],Diploid male karyotype 46,XY[16]New
10PB98UNK45,XY,t(3;3)(q21;q26.2),-7[11],43-45 XY,t(3;3)(q21;q26.2),del(4)(p14p16),-7,-8,-10,+0-5mar[cp8]Refractory
11PB73M4Diploid female karyotype 46,XX[20]New
12PB63M1Diploid male karyotype 46,XY[20]New
13BM81M4Diploid female karyotype 46,XX[20]New
14PB64Raising from MDSPseudodiploid clone 46,XX,t(5;7)(q34;p13)[17],Pseudodiploid metaphase 46,XX,t(1;8)(p22;q22)[1],Diploid female karyotype 46,XX[2]Relapse 2
  • Abbreviations: UNK, unknown (outside diagnosis); BM, bone marrow; PB, peripheral blood; FAB, French-American-British; RAEBT, refractory anemia with excess of blasts in transformation.