Table 3.

Genotyping results of the variants confirmed in the validation set

Gene, variantPrimary set, n (%)Validation set, n (%)Joint set, n (%)
Cases (197)Controls (254)OR *P *Cases (549)Controls (1,119)OR PCases (746)Controls (1,373)OR P
ADH1B, Arg48His
    Arg/Arg129 (66.5)145 (57.3)1.001.00361 (65.8)682 (61.0)1.001.00490 (65.7)827 (60.2)1.001.00
    Arg/His59 (30.5)96 (37.9)0.660.04173 (31.5)375 (33.5)0.911.00232 (31.1)471 (34.3)0.840.10
    His/His6 (3.0)12 (4.8)0.700.1715 (2.7)61 (5.5)0.590.001421 (2.8)73 (5.3)0.630.0002
    Dominant0.640.030.820.310.770.01
    Recessive0.610.330.350.00140.410.0004
MGMT, rs7087131
    G/G137 (70.6)171 (68.7)1.001.00417 (76.2)786 (70.3)1.001.00554 (74.8)957 (70.0)1.001.00
    G/A56 (28.9)65 (26.1)1.050.82115 (21.0)305 (27.3)0.740.07171 (23.1)370 (27.1)0.810.06
    A/A1 (0.5)13 (5.2)0.300.00215 (2.8)27 (2.4)0.961.0016 (2.1)40 (2.9)0.780.09
    Dominant0.890.590.760.100.790.02
    Recessive0.100.0020.981.000.630.13
  • * P and OR were adjusted for age using multivariate logistic regression analysis.

  • P and OR were adjusted for age and ethnicity using multivariate logistic regression analysis.

  • P is based on one-sided test and adjusted for age and ethnicity using multivariate logistic regression analysis and for multiple testing using Bonferroni correction.