Table 2.

Response to trastuzumab-based chemotherapy based on β1-integrin staining by immunohistochemistry

β1-Integrin membranous staining by IHC
Score 3+, n = 23 (30%)Score 0–2+, n = 55 (70%)
n (%)n (%)P*
Response
    ORR4 (17)25 (45)0.02
    SD12 (52)22 (40)0.07
    PD7 (30)8 (45)0.38
Site of progression
    Visceral 12 (53)27 (49)
    Bone + soft tissue 4 (17)12 (22)
    Brain4 (17)11 (20)
    Others3 (13)5 (9)
Progression
    Median TTP (mo)4.88.20.0089
    Progression <6 mo15 (65)19 (34)0.0146
    No progression0 (0)5 (9)
Survival
    Median survival (mo)13230.00081

Abbreviations: SD, stable disease; PD, progressive disease; ORR, objective response rate; IHC, immunohistochemistry.

  • *P values: score 3+ versus 0-2+.