Table 2.

Association of the best single SNP in each gene to CMT risk

GeneBest Praw data set 1Best Praw data set 2Best Praw totalBest PBonf totalOdds ratio totalFcases/Fcontrols total
BRCA20.00326.7 × 10−43.9 × 10−61.4 × 10−44.240.97:0.88
BRCA10.0120.181.3 × 10−40.00493.740.97:0.91
FGFR20.0180.110.00470.181.880.90:0.83
TOX30.290.0230.0140.521.800.92:0.86
CHEK20.370.0150.0341.01.400.57:0.49
MAP3K10.0250.540.0421.01.430.79:0.72
LSP10.0360.640.111.01.450.89:0.85
RCAS10.250.0630.161.01.420.91:0.88
TP530.0100.800.201.01.230.38:0.33
ERBB20.300.330.241.01.450.95:0.93
Ncases89122212212212212
Ncontrols8559143143143143

Abbreviations: Praw, the best χ2 single SNP P value obtained for each gene [nominal association (Praw < 0.05) is indicated in bold]; PBonf, Bonferroni corrected P values [significant association (PBonf < 0.05) is indicated in bold]; Fcases/Fcontrols, the risk allele frequency in cases and controls.