Table 1.

Parameter values for phenotypic traits

Cell line
pBabeneuNneuTAT1CA1aCA1d
TumorigenicNoNoNoRarelyYesYes
Experimental parameters
    Proliferation* (h)M22.36 [—]17.34 [30.14]17.33 [33.01]18.73 [24.76]15.75 [24.76]16.12 [21.66]
    Unbiased migration (μm/h) ± SEs46.96 ± 1.4158.56 ± 1.6251.06 ± 1.7047.12 ± 1.9944.59 ± 1.4957.26 ± 2.56
    ECM degradation/cell area (10−3) ± SE (10−3)δ0.32 ± 0.094.90 ± 1.324.59 ± 3.172.75 ± 1.575.82 ± 1.4512.07 ± 3.98
    Cell-cell adhesion (% dissociation) ± SEAi34.70 ± 0.7833.37 ± 2.6349.10 ± 2.8610.73 ± 1.0813.46 ± 1.4114.29 ± 1.77
Nondimensional parameters
    Proliferation* (time steps)M18,600 [—]14,400 [25,117]14,400 [27,508]15,600 [20,633]13,200 [20,633]13,400 [18,050]
    Unbiased migration (× 10−4)Dn2.644.113.992.662.383.93
    ECM degradationδ0.00160.02450.0230.01380.02910.0604
    Cell-cell adhesion indexAi221333
  • *Doubling times in brackets were obtained using serum-free, growth factor–free cell culture conditions.

  • Value normalized to MCF10A-p120-knockdown.