Table 1.

Tissue-specific TE comparison

CodeTissueTE increase (mean)Cancerous dN/dS (mean)P
C00-C14Head and neck, not otherwise specified1.4394.653
C44Skin1.4051.6410.676
C16Stomach1.3093.8140.150
C71Brain1.292.5590.137
C20Rectum1.2811.0810.192
C15Esophagus1.2756.7220.084
C18-C20Colorectum, not otherwise specified1.2662.7770.064
C67Bladder1.251.7790.140
C18Colon1.2392.880.078
C61Prostate gland1.2335.030.078
C34Bronchus and lung1.2320.50.016
C22Liver and intrahepatic bile ducts1.2220.7850.045
C32Larynx1.2183.750.262
C50Breast1.2030.830.005
C06Other and unspecified parts of mouth1.1810.5690.024
C56Ovary1.1521.3360.002
C42Hematopoietic and reticuloendothelial systems1.1241.3750.033

NOTE: For each tissue, we downloaded from ref. 25 data on mutations found in primary tumors in that tissue. Wilcoxon test was used to assign P values for the differences between the TE of the tissue with the highest mean to that of all other tissues. Only tissues with at least 100 nonsynonymous mutations are shown in the table. Code refers to the tissue's code of International Classification of Diseases for Oncology, Third Edition (49). Significant results after correcting for multiple hypotheses (false discovery rate) are boldfaced.