Table 1.

Melanocyte growth arrest program genes and its associated pathways

Multiply represented MGAP (MGAP*) genes
ADAMTSL1, AKR1C2, AOX1, APBA2, ARHGAP29, ARNTL2, ASPN, BCAT1, BGN, BMP2, BNC1, C13orf15, C1S, C4orf18, C5orf13, CCND2, CDH11, CDKN2B, CLCA2, COL1A1, COL1A2, COL3A1, COL5A1, COL6A1, COL6A2, CORIN, CPE, CYP19A1, CYP3A7, CYR61, DCN, DDAH1, DIO2, DPT, DPYSL3, DUSP1, EDNRA, EFEMP1, EGFR, EVI1, FBLN1, FERMT1, FGF1, FGF5, FIBIN, FILIP1L, FLJ30375, FLJ32255, FN1, FSCN1, GLIPR1, GLIS3, GLT8D2, GPC4, GREM1, GREM2, HGF, HMGA2, HNT, HOXA11, HS3ST3B1, HSPB6, IGF2BP3, ITGA2, ITGA4, ITGBL1, KCNK1, KIAA1462, LIFR, LOC100129105, LOC255480, LOC654433, LOC727738, LOX, LPAR1, LTBP1, LTBP2, MEG3, MEGF10, MGC16121, MGC9913, MGLL, MGST1, MICAL2, MKX, MOXD1, MSX2, NEFL, NETO1, NEXN, NNMT, NRK, NRP1, PALLD, PAPPA, PCDH18, PCSK5, PDGFC, PDGFRA, PLA2R1, PLAU, POSTN, PRRX1, PTGS1, PTPRD, PTPRF, RAC2, RCN3, RGS4, RUNX1T1, SALL1, SCN2A, SERPINE1, SFRP2, SHOX2, SHROOM3, SIM1, SIX4, SLC1A3, SLC38A1, SOX11, SOX9, STC1, STC2, STEAP3, TBX3, TBX5, TFPI2, TGM2, THBS1, THY1, TM4SF1, TNFRSF11B, TNFRSF21, TWIST2, VCAN, VGLL3, WNT5A, WNT5B, ZEB1
Pathways mapped by Ingenuity pathway analysis
PathwayPRatioMolecules
Hepatic fibrosis/hepatic stellate cell activation5.129E−070.0741COL1A2, COL1A1, FN1, HGF, PDGFRA, EDNRA, EGFR, COL3A1, TNFRSF11B, FGF1
PTEN signaling0.00190.0532RAC2, ITGA2, PDGFRA, EGFR, ITGA4
Actin cytoskeleton signaling0.00420.0315RAC2, FN1, ITGA2, PDGFC, ITGA4, FGF5, FGF1
Neuregulin signaling0.01070.0430DCN, ITGA2, EGFR, ITGA4
Pantothenate and CoA biosynthesis0.01860.0317BCAT1, DPYSL3
Wnt/β-catenin signaling0.02190.0303SOX9, SFRP2, SOX11, WNT5B, WNT5A
Ephrin receptor signaling0.02690.0266RAC2, ITGA2, PDGFC, ITGA4, FGF1
Axonal guidance signaling0.02820.0205RAC2, BMP2, ITGA2, PDGFC, WNT5B, ITGA4, WNT5A, NRP1
Arachidonic acid metabolism0.03890.0189CYP19A1, CYP3A7, PLA2R1, PTGS1
Caveolar-mediated endocytosis0.04270.0370ITGA2, EGFR, ITGA4
Metabolism of xenobiotics by cytochrome P4500.04370.0188MGST1, CYP19A1, CYP3A7, AKR1C2
FGF signaling0.04570.0357HGF, FGF5, FGF1
Coagulation system0.04900.0541PLAU, SERPINE1