Table 1.

Birth frequencies from breeding pairs with combined heterozygosity for Fancd2 and Mlh1

Strain backgroundFancd2 Mlh1 C57BL/6jFancc Mlh1 C57BL/6jFancd2 Mlh1 129S4 C57BL/6jFancd2 Mlh1 Trp53−/− 129S4 C57BL6jExpected birth frequencies
No. of mice300194240160
Genotypes
Fanc-Mlhl
    HET-HET0.3130.3610.2540.2440.250
    HET-MUT0.1030.1440.1170.1060.125
    HET-WT0.1400.1600.1790.2000.125
    MUT-HET0.0270.0520.0960.0630.125
    MUT-MUT0.000A0.000B0.021C0.013D*0.063
    MUT-WT0.0170.0360.0580.0690.063
    WT-HET0.1870.0820.1380.1310.125
    WT-MUT0.0900.0820.0710.0750.063
    WT-WT0.1230.0820.0670.1000.063

NOTE: χ2 test on observed birth frequency of double-mutant mice versus expected birth frequency of double-mutant mice: A, P < 0.0001; B, P < 0.0003; C, P = 0.0055; D, P = 0.0081.

  • *Included in this analysis is one perinatal lethal 129S4 + C57BL/6j Trp53 triple-mutant newborn.