Table 3.

Connectivity and gene significance of 20 selected hub genes

SymbolGene nameAccession numberNo. of connectionsGene significance*
rPFDRRank
CDC2Cell division cycle 2NM_001786550.4954.49E-098.92E-0743
DTLDenticleless homologueNM_016448550.4851.00E-081.68E-0651
CCNA2Cyclin A2NM_001237500.4821.30E-082.03E-0654
PLK4Polo-like kinase 4NM_014264480.4412.67E-071.78E-05128
TTKTTK protein kinaseNM_003318400.4752.26E-082.91E-0666
CEP55Centrosomal protein 55 kDaNM_018131350.4191.16E-065.32E-05186
KIF15Kinesin family member 15NM_020242260.4841.05E-081.71E-0652
CCNB2Cyclin B2NM_004701200.4161.40E-066.11E-05196
ORC1LOrigin recognition complex, subunit 1-likeNM_004153190.4916.27E-091.16E-0646
MELKMaternal embryonic leucine zipper kinaseNM_014791170.5002.82E-096.17E-0739
NCAPGNon-SMC condensin I complex, subunit GNM_022346170.3731.84E-054.36E-04360
HJURPHolliday junction recognition proteinNM_018410140.4878.30E-091.45E-0649
Ska1Spindle and KT associated 1NM_145060130.3702.12E-054.81E-04376
TPX2TPX2, microtubule-associated, homologueNM_012112130.3351.36E-041.89E-03613
TOP2ATopoisomerase (DNA) II α 170 kDaNM_001067120.4973.74E-097.78E-0741
CDCA5Cell division cycle associated 5NM_080668120.4315.31E-072.95E-05154
KIF23Kinesin family member 23NM_004856120.3791.29E-053.28E-04334
CDCA2Cell division cycle associated 2NM_152562110.3926.11E-061.90E-04274
ATAD2ATPase family, AAA domain containing 2NM_014109110.3731.86E-054.40E-04361
AURKAAurora kinase ANM_198436100.3791.34E-053.37E-04340
  • *Represents statistical significance of Pearson correlations between a specific gene expression and pathologic grade of prostate cancer.

  • Rank is based on FDR value among 13,935 genes with most significant gene as 1.