Table 1.

Association statistics for SNPs in the CASP8 gene

SBCS *Meta-analysis of three studies *
SNP Position (bp) MAF §OR (95% CI) heterozygotesOR (95% CI) rare homozygotesPtrendOR (95% CI) heterozygotesOR (95% CI) rare homozygotesPtrendPhom
rs38341292018057770.5320.90 (0.73–1.11)0.77 (0.61–0.97)0.0270.95 (0.83–1.08)0.82 (0.70–0.95)0.0080.33
rs37698262018112940.4501.05 (0.87–1.28)1.23 (0.97–1.55)0.099
rs76086922018192040.2140.94 (0.79–1.12)1.05 (0.68–1.61)0.68
rs38209722018192650.0851.11 (0.86–1.44)0.80 (0.33–1.95)0.64
rs37698252018196250.4201.10 (0.91–1.32)1.26 (0.99–1.60)0.063
rs134026162018280120.0621.12 (0.87–1.44)1.45 (0.46–4.57)0.30
rs18612692018351830.0360.87 (0.63–1.21)0.52
rs64350742018361920.2451.22 (1.02–1.45)1.17 (0.84–1.64)0.0461.12 (1.00–1.27)1.22 (0.97–1.55)0.0130.93
rs67230972018368630.3511.15 (0.96–1.37)1.36 (1.04–1.76)0.0171.14 (1.00–1.30)1.34 (1.11–1.61)0.00080.99
rs37549342018403520.0480.90 (0.66–1.23)3.06 (0.32–29.44)0.73
rs38175782018448400.0491.03 (0.77–1.38)1.06 (0.07–16.94)0.86
rs10454852018578340.1560.87 (0.72–1.05)0.59 (0.32–1.09)0.0410.91 (0.79–1.05)0.65 (0.41–1.04)0.0430.48
rs10454872018579410.0430.96 (0.71–1.30)3.04 (0.32–29.31)0.97
rs131132018604070.4500.94 (0.78–1.14)0.90 (0.71–1.15)0.39
  • * OR and 95% CIs are relative to the common homozygous reference genotype.

  • For rs3834129, ins/ins was used as the reference genotype to be consistent with published data ( 8). Largely overlapping data for rs3834129 and rs1045485 in SBCS and GC-HBOC have been published previously ( 2, 6, 8).

  • Positions are derived from dbSNP build 126.

  • § Minor allele frequency is given for SBCS controls.

  • Test for homogeneity between studies.