Table 2.

Mean (SD) genetic alterations for the discovery screen by clinical parameters

nMutationsDeletionsAmplificationsMutations, deletions, and amplifications
Mean (SD)PMean (SD)PMean (SD)PMean (SD)P
Nonsmoker1356.2 (13.9)0.087.8 (4.7)0.585.5 (5.4)0.7369.5 (16.4)0.08
Smoker1175.5 (41.7)8.8 (4.3)6.5 (9.1)90.9 (44.4)
Moderate/well grade858.1 (15.6)0.596.5 (2.7)0.232.6 (4.6)0.0667.2 (19)0.28
Poor grade1568.9 (37.4)8.7 (4.8)7.4 (7.9)84.9 (39)
Ages <70 y1660.8 (19.1)0.168.9 (4.6)0.336.6 (7.3)0.5976.2 (24.3)0.37
Ages ≥70 y873.8 (47.1)7 (4.2)4.9 (7.3)85.6 (48.2)
Black361.3 (15.9)0.697 (2)0.540.3 (0.6)0.0168.7 (17.2)0.39
White2165.6 (32.7)8.4 (4.7)6.8 (7.3)80.9 (35.1)
Female1054.3 (13.5)0.356.4 (3.6)0.083 (4.4)0.0563.7 (14.5)0.10
Male1469.3 (37)9.6 (4.7)8.1 (8.1)87 (38.7)
Nondiabetic1668.9 (36)0.348.9 (5.1)0.327.8 (7.9)0.0485.6 (37.4)0.13
Diabetic857.4 (15.9)7 (2.7)2.4 (3.9)66.8 (19.8)
Tail572.6 (24)0.887.8 (3.1)0.689 (10.9)0.3989.4 (34.1)0.76
Head1963.1 (32.7)8.4 (4.8)5.2 (6)76.7 (33.6)
Age (y)0.96 (0.55)0.10−0.12 (0.08)0.16−0.06 (0.14)0.680.77 (0.61)0.22
  • NOTE: P values for smoking-adjusted differences in the rate of mutations between patient groups. Differences between males and females exclude mutations on chromosome X. Values for age in years are regression coefficients (SE) for the average increase in the number of alterations with a yearly increase in age, adjusted for smoking status.