Table 3.

Types of mutations by smoking status for the discovery screen

Nonsmokers (n = 13)Smokers (n = 11)P
Mean (SD)Mean (SD)
Mutations56.2 (13.9)75.5 (41.7)0.06
Mutations not in KRAS, TP53, SMAD4, or CDKN2A/p1653.9 (14.1)73.5 (41.7)0.05
Mutations not in any driver gene53.2 (13.8)73.3 (41.8)0.05
Synonymous mutations14.8 (5.4)18.7 (11.3)0.26
Nonsynonymous mutations38.5 (11.1)53.1 (27.9)0.04
Transition mutations35.3 (9)43.7 (16.9)0.04
Transversion mutations20.9 (10.3)31.8 (25.9)0.16
  • NOTE: P values for differences between smokers and nonsmokers, adjusted for age and gender.