Table 4.

Frequency of specific sequence mutations and context for the discovery screen by smoking status

No. mutations in nonsmokersNo. nonsmokers with a specific mutationNo. mutations in smokersNo. smokers with a specific mutationOdds ratio (95% confidence interval)P
Sequence mutations
    A-to-C261022100.72 (0.33-1.54)0.40
    A-to-G321250111.38 (0.86-2.21)0.18
    A-to-T20929111.25 (0.69-2.27)0.46
    C-to-A361370101.6 (1.04-2.46)0.03
    C-to-G341134100.76 (0.45-1.26)0.28
    C-to-T21413197110.78 (0.57-1.07)0.13
    G-to-A18713200111.02 (0.79-1.31)0.89
    G-to-C39935100.8 (0.36-1.76)0.57
    G-to-T571383111.27 (0.88-1.85)0.20
    T-to-A862082.32 (0.99-5.45)0.05
    T-to-C26113481.15 (0.64-2.06)0.63
    T-to-G1581670.85 (0.41-1.79)0.68
    Insertion or deletion371341111.01 (0.63-1.63)0.96
Context
    A7813101111.07 (0.78-1.48)0.66
    C9013104110.91 (0.67-1.25)0.57
    C *pG15213140110.82 (0.6-1.12)0.21
    CpG *12813143111.16 (0.8-1.69)0.43
    G9213119111.11 (0.82-1.5)0.49
    G *pA631256110.79 (0.41-1.53)0.49
    T491270111.25 (0.81-1.92)0.31
    TpC *421257101.16 (0.76-1.77)0.49
All sequence mutations73113831111.26 (0.74-2.15)0.40
  • NOTE: Odds ratios for having each specific type of mutation for smokers versus nonsmokers, adjusted for age and gender.

  • * Altered base.