Table 6.

Frequency distribution of the number of sequencing mutations in KRAS, SMAD4, TP53, and CDKN2A/p16 and all other genes by mutation type and context, comparing nonsmokers and smokers, adjusted for age and gender

KRASSMAD4TP53CDKN2A/p16
NonsmokersSmokersPNonsmokersSmokersPNonsmokersSmokersPNonsmokersSmokersP
Sequence mutations
    A-to-C120.9910>0.9901>0.9901>0.99
    A-to-G01>0.9902>0.99430.8900
    A-to-T0000210.9901>0.99
    C-to-A0000120.9901>0.99
    C-to-G0010>0.99120.99120.85
    C-to-T00630.17910>0.99460.32
    G-to-A26340.903>0.999120.5802>0.99
    G-to-C6100.9901>0.9910>0.9901>0.99
    G-to-T17170.37210.91540.85110.99
    Insertion or deletion00470.391180.36240.77
    T-to-A0000>0.99120.9900
    T-to-C0010>0.99230.9900
    T-to-G0000120.9901>0.99
Context
    A130.99120.99650.8602>0.99
    C0010>0.9922>0.9925>0.99
    C *pG00410.148110.99340.34
    CpG *0000580.9700
    G49610.99140.98470.9903>0.99
    G *pA00110.99610.67110.99
    T0010>0.99470.9901>0.99
    TpC *0022>0.9911>0.9900
Total mutations5064>0.9915170.124750>0.998200.02
  • NOTE: Some patients had more than one mutation on an individual gene, and total represents the number of mutations across all patients within smoking category.

  • * Altered base.