Table 1.

Immunohistochemical analysis in BMB from CD38+CD49d+ and CD38CD49d CLL

#BM *CCL3 CD68 VCAM-1
CD38CD49d CLL3840(N)11
3945(N + I)22
4040(N + I)22
4190(D)21
4250(N + I)11
4345(N)00
4490(D)+22
4550(N + I)11
4650(N + I)11
4740(N + I)21
CD38+CD49d+ CLL4890(D)+33
4940(N + I)+32
5070(D)22
5150(N)+33
5250(N + I)+22
5345(N + I)22
5490(D)+33
5550(N + I)+22
5660(N + I)22
5740(N + I)+32
  • Abbreviations: N, nodular; I, interstitial; D, diffuse.

  • * Figures refer to percent BM infiltration; patterns of infiltration are reported in parenthesis.

  • Negative (−) and positive (+) expression was determined as reported in Materials and Methods.

  • CD68 and VCAM expression was evaluated by two different semiquantitative four-tier grading systems (from grade 0 to grade 3).