Table 2.

Urinary nicotine metabolite profile in 104 smokers

% of Total-NIC-Eq*Creatinine-adjusted levels (nmol/mg creatinine)
Mean ± SD (95% CI)RangeMean ± SD (95% CI)Range
3HC33.6 ± 8.7 (32.0-35.4)5.9-53.442.4 ± 25.2 (37.6-47.3)0.78-145
3HC-Gluc16.7 ± 7.8 (15.1-18.2)3.3-43.621.8 ± 18.5 (18.2-25.3)0.44-124
Cotinine11.0 ± 6.6 (9.8-12.2)2.9-32.014.2 ± 11.9 (11.9-16.5)0.97-70
Nicotine10.6 ± 7.3 (9.2-12.0)0.58-31.712.9 ± 11.5 (11.0-15.2)0.42-64
4HPBA8.9 ± 3.7 (8.1-9.6)3.1-32.310.6 ± 6.0 (9.4-11.8)0.95-37
Cotinine-Gluc7.3 ± 3.4 (6.6-8.0)0-18.88.7 ± 5.3 (7.6-9.7)0.00-26
Nicotine-N′-oxide4.8 ± 2.5 (4.3-5.3)1.4-13.45.6 ± 3.2 (4.9-6.2)0.36-18
Nicotine-Gluc4.3 ± 3.4 (3.6-4.9)0-19.55.0 ± 4.6 (4.2-5.8)0.00-31
Cotinine-N-oxide2.8 ± 0.77 (2.7-3.0)1.2-5.03.4 ± 1.6 (7.6-9.7)0.58-8.1
  • *Ratio of individual nicotine metabolite (μmol/L) measured as a percentage of total urinary nicotine metabolites [Total-NIC-Eq (μmol/L)].

  • Ratio of individual nicotine metabolite (μmol/L) to urinary creatinine (mg/mL).

  • 95% CI, 95% confidence interval.