Table 1.

Risk of Merkel cell carcinoma associated with serostatus to MCPyV ST-Ag and LT-Ag

AntigenSerostatusControls (n = 530)Cases (n = 139)OR (95% CI)
n (%)n (%)
MCPyV ST-Ag525 (99.1)88 (63.3)1.0 (reference)
+5 (0.9)51 (36.7)63.2 (24.4–164.0)
MCPyV LT-Ag521 (98.3)108 (77.7)1.0 (reference)
+9 (1.7)31 (22.3)16.9 (7.8–36.7)
BKV ST-Ag524 (98.9)138 (99.3)1.0 (reference)
+6 (1.1)1 (0.7)0.6 (0.1–5.3)
BKV LT-Ag519 (97.9)136 (97.8)1.0 (reference)
+11 (2.1)3 (2.2)1.0 (0.3–3.8)

NOTE: One hundred and thirty-nine initial U.S. MCC cases are included along with 530 U.S. population controls matched to these cases in a 4:1 manner by 5-y age and gender. ORs have been adjusted for age at blood draw and gender. Cut points used to determine positivity (based on 3 SDs above the mean of controls): men: MCST-Ag, 1,058; MCLT-Ag, 3,280; BKST-Ag, 3,683; BKLT-Ag, 6,134; women: MCST-Ag, 818; MCLT-Ag, 2,110; BKST-Ag, 3,021; BKLT-Ag, 4,216.