Table 1.

Summary of responses in patients evaluated with multiple pharmacodynamic readouts in tumor and skin biopsies

Tumor biopsiesSkin biopsies
PT IDaTumor typeDose,b mgAligned chromosomes (% predose minus % day 7)Bipolar spindles (% predose minus % day 7)Mitotic index (day 7 minus predose)Mitotic index (day 7 average minus predose)
111Colorectal251c70.70.26
112Colorectal25−4d2−3.20.00
125Pancreatic35−66−0.20.35
129Colorectal6033492.7−0.02
142Melanoma60−12−12−1.20.06
130Colorectal7038340.43.25
131NSCLC703830−0.9−0.23
147Colorectal7043442.40.95
153Colorectal8055532.93.73

Abbreviation: NSCLC, non–small cell lung cancer.

  • aPatient identification.

  • bDose cohort.

  • cPositive values are in a direction consistent with Aurora A inhibition.

  • dNegative values are in a direction not consistent with Aurora A inhibition.