Table 1.

Average PK parameter values (mean ± SD) following i.v. injection (jugular) of docetaxel in marketed diluted solution (Taxotere) and docetaxel-loaded NCs (NCs) or oral administration of docetaxel-loaded NCs embedded in microparticles at the same dose of 5 mg/kg), N = 4

Intravenous PK study formulationCmax, ng/mLAUC, h ng/mLT1/2, hCL, L/h/kg
1. Docetaxel solution (i.v.)2,080 ± 81.2a2.9 ± 0.42.4 ± 0.1
2. Docetaxel NCs (i.v.)1,441.9 ± 485.6b4.7 ± 0.13.8 ± 1.3a
3. Docetaxel–PLGA4K double-coated NCs, BI (oral)8,82.6 ± 1,11.95,754.5 ± 1,338.8a,b1.9 ± 0.70.9 ± 0.2a

AUC and CL of 1 vs. 2 P > 0.05 ns

  • aAUC of 1 vs. 3 P < 0.01 significantly and CL of 2 vs. 3 P < 0.01 significantly.

  • bAUC of 2 vs. 3 P < 0.001 and CL of 1 vs. 3 P > 0.05 nonsignificant.