Table 3.

Gene–environment interactions with Pinteraction < 0.01

Fixed effects meta-analysis
SNP/chromosomal location/environmental variableORINT (95% CI)nom.padj.phet.pStudies
rs16892766/8q23.3/Vegetable quartile medians1.88 (1.36–2.59)1.3 × 10–40.020.68ARCTIC/DALS/PLCO/WHI/HPFS/NHS/PHS
rs16892766/8q23.3/Fiber quartile medians1.33 (1.13–1.56)6.0 × 10–40.090.87DALS/PLCO/WHI/HPFS/NHS
rs4939827/18q21/Red meat above/below median1.14 (1.05–1.24)2.9 × 10–30.360.59ARCTIC/DALS/PLCO/WHI/DACHS/ASTERISK/HPFS/NHS/PHS
rs16892766/8q23.3/Vegetables above/below median1.29 (1.09–1.53)3.5 × 10–30.400.31ARCTIC/DALS/PLCO/WHI/DACHS/ASTERISK/HPFS/NHS/PHS
rs3802842/11q23/Folate quartile medians1.34 (1.08–1.67)8.2 × 10−30.710.65DALS/PLCO/WHI/HPFS/NHS
rs3802842/11q23/Red meat quartile medians1.17 (1.04–1.32)8.6 × 10−30.730.58ARCTIC/DALS/PLCO/WHI/HPFS/NHS/PHS

NOTE: Permutation-based significance threshold, 3.75 × 10−4; Bonferroni-based significance threshold, 2.78 × 10−4.

Abbreviations: ORINT, multiplicative interaction OR from EB; 95% CI for ORinteraction; nom.p, nominal P value; adj.p, adjusted P value based on permutations; het.p, Pheterogeneity; Studies, studies included in estimating the interaction term.