Table 2.

Associations between SNPs and CRC risk in previously published reports and this study

Chromosomal locationGene/locusSNPMinor alleleOther alleleMAFPublished OR (95% CI)aPublished ref.Current study OR (95% CI)a,bCurrent study P valueaCurrent study, NCurrent study, NAc
8q23.3EIF3H/UTP23rs16892766CA0.091.25 (1.19–1.32)(2)1.17 (1.08–1.27)1.6 × 10−416,77568
8q24MYCrs6983267AC0.480.83 (0.81–0.85)(3, 7)0.88 (0.84–0.93)4.1 × 10−715,6571,186
10p14LOC338591rs10795668AG0.310.89 (0.86–0.91)(2)0.97 (0.93–1.02)0.2516,78261
11q23LOC120376rs3802842CA0.291.11 (1.08–1.15)(5)1.12 (1.06–1.17)2.1 × 10−516,76974
14q22.2BMP4rs4444235GA0.471.09 (1.06–1.12)(8)1.05 (1.01–1.11)0.0315,3221,521
15q13CRAC1/GREM1rs4779584AG0.201.15 (1.10–1.19)(6)1.15 (1.08–1.21)2.1 × 10−616,77568
16q22.1CDH1rs9929218AG0.300.91 (0.89–0.94)(8)0.94 (0.89–0.99)0.0116,728115
18q21SMAD7rs4939827GA0.480.83 (0.81–0.86)(5)0.90 (0.86–0.94)2.0 × 10−616,76281
19q13.1RHPN2rs10411210AG0.100.87 (0.83–0.91)(8)0.96 (0.89–1.04)0.3016,74796
20p12.3BMP2rs961253AC0.361.12 (1.09–1.15)(8)1.12 (1.07–1.18)1.3 × 10−616,78360

Abbreviations: N, number; NA, not available.

  • aOR and P values for log-additive model; OR represents each additional copy of the minor allele.

  • bPresented ORs for current data are based on subjects that overlap with main effects previously published (10).

  • cNA, number missing for each SNP. 8q24 has a higher proportion missing because it was not successfully genotyped using BeadXpress.