Table 3.

Association between caffeinated coffee and decaffeinated coffee consumption and BCC risk in the NHS (1984–2008) and the HPFS (1986–2008)

Women (NHS)Men (HPFS)
CasesPerson-yearsAge-adjusted RRMV-adjusted RRCasesPerson-yearsAge-adjusted RRMV-adjusted RR
Caffeinated coffee (cup)
 <1/mo2,692275,5191.001.002,497193,9841.001.00
 1/mo–1/d3,908384,0480.97 (0.92–1.02)0.94 (0.89–0.99)3,411253,8431.00 (0.95–1.05)0.99 (0.93–1.04)
 1–2/d2,904259,4521.00 (0.95–1.06)0.95 (0.89–1.00)1,24494,5330.92 (0.86–0.99)0.90 (0.84–0.97)
 2–3/d3,053325,4440.93 (0.88–0.98)0.91 (0.85–0.96)1,00799,8460.86 (0.80–0.92)0.92 (0.85–1.00)
 >3/d1,673224,7040.78 (0.74–0.83)0.79 (0.74–0.85)39746,0900.80 (0.72–0.90)0.90 (0.80–1.01)
Ptrend<0.0001<0.0001<0.00010.003
Decaffeinated coffee (cup)
 <1/mo4,515537,8321.001.003,027274,2761.001.00
 1/mo–1/d6,052584,9111.12 (1.08–1.16)1.06 (1.01–1.11)3,855288,0741.12 (1.07–1.18)1.08 (1.03–1.14)
 1–2/d2,165192,0841.16 (1.10–1.22)1.12 (1.06–1.19)88057,6891.15 (1.06–1.24)1.07 (0.99–1.16)
 2–3/d1,109110,4301.13 (1.06–1.20)1.08 (1.00–1.17)56847,6441.04 (0.95–1.13)1.06 (0.96–1.16)
 >3/d38943,9101.03 (0.93–1.14)0.98 (0.87–1.10)22620,6130.95 (0.83–1.09)1.00 (0.87–1.15)
Ptrend0.0030.010.780.81

NOTE: MV-adjusted RR: multivariate-adjusted for BMI (3 groups), physical activity (quintiles), smoking status (never, past, current 1–14 cigarettes per day, 15+ cigarettes per day), childhood reaction to sun, severe sunburns, moles, hair color, family history of melanoma, sun exposures at different age intervals, UV index at birth, age 15, and age 30, and history of nonskin cancer.