Table 2.

Analysis for OS in patients with MCL

OS (mo) Multivariate analysis
VariableNEvents5-year OS (95% CI)PRR95% CIP
Agea0.0191.031.01–1.060.001
Gender0.514
 Female252061 (42–80)
 Male985856 (46–66)
LDH<0.001
 Low452372 (59–85)
 High292317 (3–31)
Lymphocytes (log10 L/mm3)0.22
 ≥4422246 (31–61)
 <4402338 (23–53)
Nodal presentation0.004
 No381781 (69–93)
 Yes805347 (36–58)
Morphology0.001
 Classical644257 (45–69)
 Blastoid221823 (5–41)
Ki67<0.001
 High (≥35%)453053 (38–68)
 Low (<35%)221818 (2–34)
IGHV gene0.0042.011.08–3.740.029
 Mutated (<97%)401884 (73–95)
 Unmutated (≥97%)806450 (39–61)
SOX11 expression0.0032.441.22–4.90.012
 Negative341484 (72–96)
 Positive1006648 (38–58)
TP53 statusb<0.001
 Wild-type311459 (42–76)
 Mutated191719 (1–37)
17p/TP53b<0.001
 Not altered602453 (40–66)
 Altered282225 (9–41)
  • aAge was treated as a continuous variable.

  • bSurvival for TP53 and 17p/TP53 alterations was calculated from the time of sample assessment instead of from time of diagnosis.