Table 1.

Sensitivity of leukemic cell lines to PFI-1

Cell lineCell typeGI50 [μmol/L]
MV4;11Childhood B-cell myelomonocytic acute leukemia (MLL/AF4)1.5 ± 1
THP-1Acute monocytic leukemia (MLL/AF9)4 ± 2
KASUMI-1Acute myeloid leukemia with t(8;21) translocation (AML1-ETO)0.8 ± 1
NALM-17Pre B-blast ALL8 ± 4
TOM-1Ph1-positive ALL3 ± 5
REHAdult ALL9 ± 4
SD-1Epstein-Barr virus immortalizedimmortalized Ph-1 positive ALL8 ± 3
NALM-6Pre-B ALL [t(5; 12) (q33; p13)]8 ± 3
NOMO-1Acute monocytic leukemia (MLL/AF9)3 ± 3
SEMKH2Acute monocytic leukemia (MLL/AF9)2 ± 2
RS4;11Acute monocytic leukemia (MLL/AF4)2 ± 2
KOCL-45Acute monocytic leukemia (MLL/AF4)10 ± 5
U937Leukemic monocytic lymphoma5 ± 3
PL21Acute promyelolytic leukemia10 ± 5
SUPB-15Ph+ childhood B-cell ALL11 ± 4
K-562Erythroleukemia CML blast (Bcr-ABL)>20