Table 1.

Top 30 core regulators (CONEXIC) ordered by decreasing CONEXIC scores

RankaCore regulatorTypeNbChromosome
1PAQR4AMP6316p
2TPX2AMP11120q
3UBE2CAMP10820q
4RPL12P14DEL701p
5RPS3AP49DEL4618q
6EXO1AMP1221q
7PTTG3PAMP448q
8SHARPINAMP588q
9RPL17DEL10618q
10TSEN54AMP6417q
11LSM14BAMP11720q
12LOC253482DEL669p
13PHBAMP6517q
14DCAF13AMP1268q
15MYBL2AMP7620q
16EIF2C2AMP1118q
17C8orf76AMP928q
18TACO1AMP6817q
19PSMD12AMP3617q
20UBE2TAMP651q
21MRPL12AMP7817q
22AURKAAMP6220q
23PKMYT1AMP5216p
24ATP6V1C1AMP858q
25RPS13P2DEL331p
26SLC52A2AMP868q
27THSD1DEL44713q
28TMEM189AMP10020q
29TPT1DEL5713q
30KIF14AMP1121q

NOTE: Amplified core regulators (AMP) showed recurrent copy-number gains and deleted core regulators (DEL) show recurrent copy number loss in high wGII tumors.

  • aRanked by CONEXIC score;

  • bNumber of genes in the module.