Table 2.

Immunogenic proteins identified by autoantibody responses from patients with TNBC to MDA-MB-231 cancer cell lysate

GeneDescriptionSubcellular localizationCase-to-control ratioqAUC
ACTA1Actin, alpha 1, skeletal muscleCytoplasm2.171.59E−030.825
ACTA2Actin, alpha 2, smooth muscle, aortaCytoplasm2.171.59E−030.825
ACTBActin, betaCytoplasm2.344.30E−050.959
ACTC1Actin, alpha, cardiac muscle 1Cytoplasm2.344.30E−050.959
ACTG1Actin, gamma 1Cytoplasm2.171.59E−030.825
ACTG2Actin, gamma 2, smooth muscle, entericCytoplasm2.171.59E−030.825
AHNAKAHNAK nucleoproteinNucleus2.504.73E−030.846
BADBCL2-associated agonist of cell deathCytoplasm2.552.06E−050.923
CALUCalumeninCytoplasm2.134.58E−030.811
CLTAClathrin, light chain APlasma Membrane2.414.46E−030.861
CLTBClathrin, light chain BPlasma Membrane2.298.71E−050.899
DCDDermcidinExtracellular Space2.002.32E−030.837
DNAH11Dynein, axonemal, heavy chain 11Cytoplasm2.414.46E−030.861
EIF4BEukaryotic translation initiation factor 4BCytoplasm2.711.62E−040.923
HIST1H1CHistone cluster 1, H1cNucleus2.344.30E−050.959
HIST1H1DHistone cluster 1, H1dNucleus2.142.18E−030.855
HIST1H1EHistone cluster 1, H1eNucleus2.072.80E−040.876
HIST1H1THistone cluster 1, H1tNucleus2.791.17E−030.852
HNRNPKHeterogeneous nuclear ribonucleoprotein KNucleus2.062.54E−030.834
HSPA5Heat shock 70-kDa protein 5Cytoplasm2.498.01E−030.802
KRT1Keratin 1Cytoplasm2.081.17E−030.828
KRT10Keratin 10Cytoplasm2.107.97E−030.858
KRT14Keratin 14Cytoplasm2.041.42E−030.899
KRT16Keratin 16Cytoplasm2.772.09E−030.899
KRT2Keratin 2Cytoplasm2.284.96E−030.817
KRT5Keratin 5Cytoplasm2.041.42E−030.899
KRT6AKeratin 6APlasma membrane2.772.09E−030.899
KRT9Keratin 9Cytoplasm2.075.13E−040.882
LASP1LIM and SH3 protein 1Cytoplasm2.381.92E−030.879
MRPS36Mitochondrial ribosomal protein S36Cytoplasm2.376.47E−030.817
NUCB1Nucleobindin 1Cytoplasm2.372.01E−030.828
P4HBProlyl 4-hydroxylase, beta polypeptideCytoplasm2.552.06E−050.923
PDIA3Protein disulfide isomerase family A, member 3Cytoplasm2.062.54E−030.834
PRKCSHProtein kinase C substrate 80K-HCytoplasm2.022.28E−030.831
RCN1Reticulocalbin 1, EF-hand calcium-binding domainCytoplasm2.178.84E−050.923
RPLP2Ribosomal protein, large, P2Cytoplasm2.361.02E−040.932
RPS21Ribosomal protein S21Cytoplasm2.298.71E−050.899
RPS27ARibosomal protein S27aCytoplasm2.133.81E−040.911
SF3B1Splicing factor 3b, subunit 1, 155 kDaNucleus2.332.02E−040.893
SLIRPSRA stem-loop interacting RNA-binding proteinCytoplasm2.377.66E−030.811
SFRS1Serine/arginine-rich splicing factor 1Nucleus2.232.02E−040.914
SFRS2Serine/arginine-rich splicing factor 2Nucleus2.006.69E−040.882
SFRS3Serine/arginine-rich splicing factor 3Nucleus2.791.17E−030.852
SFRS7Serine/arginine-rich splicing factor 7Nucleus2.361.02E−040.932
SFRS9Serine/arginine-rich splicing factor 9Nucleus2.791.17E−030.852
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1Cytoplasm2.133.81E−040.911
UBBUbiquitin BCytoplasm2.536.71E−030.846
UBCUbiquitin CCytoplasm2.536.71E−030.846
ZYXZyxinPlasma membrane2.062.54E−030.834