Table 1.

Clinical characteristics and number of genomic alterations in 442 patients with CUP

Basic characteristics (N = 442)
 Age, median (range), year65 (20–94)
 Female, N (%)231 (52.3%)
 Male, N (%)211 (47.7%)
Genomic alterations in 442 cases of CUP
 Number of alterationsa1368
 Mean number of alterations per patient (range) (includes characterized alterations and VUS)3.1 (0–20)
 Median number of alterations per patient (range) (includes characterized alterations and VUS)2 (0–20)
 Number of characterized alterations768 (56.1%)
 Mean number of characterized alterations per patient (range)1.7 (0–10)
 Median number of characterized alterations per patient (range)1 (0–10)
 Substitution, N (%)507 (37.1%)
 Amplification, N (%)257 (18.8%)
 Fusion, N (%)3 (0.22%)
 Indel, N (%)1 (0.07%)
 Variant of unknown significance, N (%)600 (43.9%)
 Number of patients with ≥1 alteration (%)a353 (79.9%)
 Number of patients with ≥1 characterized alteration (%)290 (65.6%)
 Number of patients with ≥2 characterized alterations (%)194 (43.9%)
  • aIncludes both characterized alterations and variants of unknown significance (VUS).