Table 1.

Number of simulations performed for each combination of parameter values (Embedded Image, μd)

Embedded ImageμdNumber of realizationsNumber of simulations that reached 109 cellsPercentage of simulations that reached 109 cellsMean number of generations to detectionMean time to detection (years)
0.11 × 10−810,1551621.6%1,596.6617.50
0.11 × 10−71,9481125.7%475.085.21
0.11 × 10−674813417.9%158.541.74
0.11 × 10−574811114.8%147.501.62
0.011 × 10−86,8671251.8%1,807.6319.80
0.011 × 10−76,8661131.6%1,406.7515.41
0.011 × 10−66,8661201.7%1,263.8013.85
0.011 × 10−56,8651151.7%1,018.4011.16
0.0051 × 10−811,9511020.9%2,552.7027.97
0.0051 × 10−711,7511121.0%2,546.8527.91
0.0051 × 10−611,7501261.1%2,046.7822.43
0.0051 × 10−511,7501000.9%1,668.0718.28
Total88,26514321.6%
  • NOTE: The mean time from initiation to clinical detection of a simulated tumor is shown. The generation time assigned in the simulations is 4 days.