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The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff.

 

Announcing our new Impact Factor: 9.727

From the Current Issue

  • A Premalignant Cell-Based Model for Functionalization and Classification of <em>PTEN</em> Variants
    Molecular Cell Biology
    A Premalignant Cell-Based Model for Functionalization and Classification of PTEN Variants
    Jesse T. Chao, Rocio Hollman, Warren M. Meyers, Fabian Meili, Kenneth A. Matreyek, Pamela Dean, Douglas M. Fowler, Kurt Haas, Calvin D. Roskelley and Christopher J.R. Loewen
    Cancer Res July 1 2020 80 (13) 2775-2789; DOI:10.1158/0008-5472.CAN-19-3278

    Combined three-dimensional tumor spheroid modeling and machine learning classifies PTEN missense variants, over 70% of which are currently listed as variants of uncertain significance.

  • A Novel Micropeptide Encoded by Y-Linked LINC00278 Links Cigarette Smoking and AR Signaling in Male Esophageal Squamous Cell Carcinoma
    Molecular Cell Biology
    A Novel Micropeptide Encoded by Y-Linked LINC00278 Links Cigarette Smoking and AR Signaling in Male Esophageal Squamous Cell Carcinoma
    Siqi Wu, Liyuan Zhang, Jieqiong Deng, Binbin Guo, Fang Li, Yirong Wang, Rui Wu, Shenghua Zhang, Jiachun Lu and Yifeng Zhou
    Cancer Res July 1 2020 80 (13) 2790-2803; DOI:10.1158/0008-5472.CAN-19-3440

    Posttranscriptional modification of a micropeptide-encoding lncRNA is negatively impacted by cigarette smoking, disrupting negative regulation of the AR signaling pathway in male ESCC.

  • Molecular Cell Biology
    RNF168-Mediated Ubiquitin Signaling Inhibits the Viability of BRCA1-Null Cancers
    John J. Krais, Yifan Wang, Andrea J. Bernhardy, Emma Clausen, Jessica A. Miller, Kathy Q. Cai, Clare L. Scott and Neil Johnson
    Cancer Res July 1 2020 80 (13) 2848-2860; DOI:10.1158/0008-5472.CAN-19-3033

    This study explores the concept that homologous recombination DNA repair is not an all-or-nothing concept, but a spectrum, and that where a tumor stands on this spectrum may have therapeutic relevance.

See the Table of Contents

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