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From the Current Issue

  • Tumor Biology and Immunology | AuthorChoice
    YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer
    Hazel M. Quinn, Regina Vogel, Oliver Popp, Philipp Mertins, Linxiang Lan, Clemens Messerschmidt, Alexandro Landshammer, Kamil Lisek, Sophie Château-Joubert, Elisabetta Marangoni, Elle Koren, Yaron Fuchs and Walter Birchmeier
    Cancer Res April 15 2021 81 (8) 2116-2127; DOI:10.1158/0008-5472.CAN-20-2801

    These findings show that YAP cooperates with β-catenin in basal-like breast cancer to regulate CSCs and that targeting this interaction may be a novel CSC therapy for patients with basal-like breast cancer.

  • Translational Science
    T Cells Expanded from PD-1+ Peripheral Blood Lymphocytes Share More Clones with Paired Tumor-Infiltrating Lymphocytes
    Tiepeng Li, Lingdi Zhao, Yonghao Yang, Yao Wang, Yong Zhang, Jindong Guo, Guangyu Chen, Peng Qin, Benling Xu, Baozhen Ma, Fang Zhang, Yiman Shang, Qingjun Li, Kai Zhang, Dongfeng Yuan, Chaojie Feng, Yan Ma, Zhiyong Liu, Zhichao Tian, Hongle Li, Shengdian Wang and Quanli Gao
    Cancer Res April 15 2021 81 (8) 2184-2194; DOI:10.1158/0008-5472.CAN-20-2300

    This study harnesses the tumor reactivity of PD-1+ PBLs, developing a method to expand T cells from these clones as a potential therapeutic strategy and TIL substitute in patients with cancer.

  • Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer
    Translational Science
    Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer
    Martina Di Modica, Giorgio Gargari, Viola Regondi, Arianna Bonizzi, Stefania Arioli, Beatrice Belmonte, Loris De Cecco, Elena Fasano, Francesca Bianchi, Alessia Bertolotti, Claudio Tripodo, Laura Villani, Fabio Corsi, Simone Guglielmetti, Andrea Balsari, Tiziana Triulzi and Elda Tagliabue
    Cancer Res April 15 2021 81 (8) 2195-2206; DOI:10.1158/0008-5472.CAN-20-1659

    Evidence of gut microbiota involvement in trastuzumab efficacy represents the foundation for new therapeutic strategies aimed at manipulating commensal bacteria to improve response in trastuzumab-resistant patients.

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