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From the Current Issue

  • Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD
    Tumor Biology and Immunology
    Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD
    Hsin-Fang Tu, Chun-Jung Ko, Ching-Tai Lee, Cheng-Fan Lee, Shao-Wei Lan, Hsin-Hsien Lin, Hsin-Ying Lin, Chia-Chi Ku, Der-Yen Lee, I-Chun Chen, Ya-Hui Chuang, Francisco Del Caño-Ochoa, Santiago Ramón-Maiques, Chao-Chi Ho, Ming-Shyue Lee and Geen-Dong Chang
    Cancer Res June 15 2021 81 (12) 3270-3282; DOI:10.1158/0008-5472.CAN-20-3436

    This study elucidates a mechanism of afatinib-mediated immunosuppression and provides new insights into treatment timing for combined targeted therapy and immunotherapy.

  • Tumor Biology and Immunology
    NPM–ALK-Induced Reprogramming of Mature TCR-Stimulated T Cells Results in Dedifferentiation and Malignant Transformation
    Jan M. Pawlicki, David L. Cookmeyer, Damian Maseda, John K. Everett, Fang Wei, Hong Kong, Qian Zhang, Hong Y. Wang, John W. Tobias, David M. Walter, Kelly M. Zullo, Sarah Javaid, Amanda Watkins, Mariusz A. Wasik, Frederic D. Bushman and James L. Riley
    Cancer Res June 15 2021 81 (12) 3241-3254; DOI:10.1158/0008-5472.CAN-20-2297

    This investigation into malignant transformation of T cells uncovers a requirement for TCR triggering, elucidates integral signaling complexes nucleated by NPM–ALK, and delineates dynamic transcriptional changes as a T cell transforms.

  • Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer
    Tumor Biology and Immunology
    Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer
    Adam C. Mueller, Miles Piper, Andrew Goodspeed, Shiv Bhuvane, Jason S. Williams, Shilpa Bhatia, Andy V. Phan, Benjamin Van Court, Kathryn L. Zolman, Brisa Peña, Ayman J. Oweida, Sara Zakem, Cheryl Meguid, Michael W. Knitz, Laurel Darragh, Thomas E. Bickett, Jacob Gadwa, Luisa Mestroni, Matthew R.G. Taylor, Kimberly R. Jordan, Peter Dempsey, M. Scott Lucia, Martin D. McCarter, Marco Del Chiaro, Wells A. Messersmith, Richard D. Schulick, Karyn A. Goodman, Michael J. Gough, Casey S. Greene, James C. Costello, Antonio Galveo Neto, David Lagares, Kirk C. Hansen, Adrie Van Bokhoven and Sana D. Karam
    Cancer Res June 15 2021 81 (12) 3255-3269; DOI:10.1158/0008-5472.CAN-20-3892

    Targeting a previously unidentified adaptive resistance mechanism to radiation therapy in PDAC tumors in combination with radiation therapy could increase survival of the 40% of PDAC patients with locally advanced disease.

  • Translational Science
    Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining
    Qin Zhou, Michelle E. Howard, Xinyi Tu, Qian Zhu, Janet M. Denbeigh, Nicholas B. Remmes, Michael G. Herman, Chris J. Beltran, Jian Yuan, Patricia T. Greipp, Judy C. Boughey, Liewei Wang, Neil Johnson, Matthew P. Goetz, Jann N. Sarkaria, Zhenkun Lou and Robert W. Mutter
    Cancer Res June 15 2021 81 (12) 3333-3346; DOI:10.1158/0008-5472.CAN-20-2960

    Coadministration of an ATM inhibitor rewires DNA repair machinery to render cancer cells uniquely hypersensitive to DNA damage induced by the proton Bragg peak, which is characterized by higher density ionization.

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