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The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff.
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Announcing our new Impact Factor: 9.727

From the Current Issue

  • Molecular Cell Biology
    EZH2-Mediated Downregulation of the Tumor Suppressor DAB2IP Maintains Ovarian Cancer Stem Cells
    Xingyue Zong, Weini Wang, Ali Ozes, Fang Fang, George E. Sandusky and Kenneth P. Nephew
    Cancer Res October 15 2020 80 (20) 4371-4385; DOI:10.1158/0008-5472.CAN-20-0458

    These findings show that combining an epigenetic therapy with a noncanonical WNT signaling pathway inhibitor has the potential to eradicate ovarian cancer stem cells and to prevent ovarian cancer recurrence.

  • Genome and Epigenome | AuthorChoice
    Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas
    Elizabeth Lenkiewicz, Smriti Malasi, Tara L. Hogenson, Luis F. Flores, Whitney Barham, William J. Phillips, Alexander S. Roesler, Kendall R. Chambers, Nirakar Rajbhandari, Akimasa Hayashi, Corina E. Antal, Michael Downes, Paul M. Grandgenett, Michael A. Hollingsworth, Derek Cridebring, Yuning Xiong, Jeong-Heon Lee, Zhenqing Ye, Huihuang Yan, Matthew C. Hernandez, Jennifer L. Leiting, Ronald M. Evans, Tamas Ordog, Mark J. Truty, Mitesh J. Borad, Tannishtha Reya, Daniel D. Von Hoff, Martin E. Fernandez-Zapico and Michael T. Barrett
    Cancer Res October 15 2020 80 (20) 4324-4334; DOI:10.1158/0008-5472.CAN-20-0078

    These data provide a unique description of the ASCP genomic and epigenomic landscape and identify candidate therapeutic targets for this dismal cancer.

  • Translational Science
    IL2RA Promotes Aggressiveness and Stem Cell–Related Properties of Acute Myeloid Leukemia
    Chi Huu Nguyen, Angela Schlerka, Alexander M. Grandits, Elisabeth Koller, Emiel van der Kouwe, George S. Vassiliou, Philipp B. Staber, Gerwin Heller and Rotraud Wieser
    Cancer Res October 15 2020 80 (20) 4527-4539; DOI:10.1158/0008-5472.CAN-20-0531

    This study identifies IL2RA as a potential therapeutic target in AML, where it is shown to regulate proliferation, differentiation, apoptosis, stem cell–related properties, and leukemogenesis.

See the Table of Contents

Recent Reviews

  • Reviews
    Exosomal Noncoding RNAs and Tumor Drug Resistance
    Chengyao Guo, Jinbo Liu, Quanbo Zhou, Junmin Song, Zhiyong Zhang, Zhen Li, Guixian Wang, Weitang Yuan and Zhenqiang Sun
    Cancer Res October 15 2020 80 (20) 4307-4313; DOI:10.1158/0008-5472.CAN-20-0032

  • Reviews
    Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines
    Manuel Valiente, Amanda E.D. Van Swearingen, Carey K. Anders, Amos Bairoch, Adrienne Boire, Paula D. Bos, Diana M. Cittelly, Neta Erez, Gino B. Ferraro, Dai Fukumura, Brunilde Gril, Meenhard Herlyn, Sheri L. Holmen, Rakesh K. Jain, Johanna A. Joyce, Mihaela Lorger, Joan Massague, Josh Neman, Nicola R. Sibson, Patricia S. Steeg, Frits Thorsen, Leonie S. Young, Damir Varešlija, Adina Vultur, Frances Weis-Garcia and Frank Winkler
    Cancer Res October 15 2020 80 (20) 4314-4323; DOI:10.1158/0008-5472.CAN-20-0291

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