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From the Current Issue

  • Convergence and Technologies
    Label-Free Deep Profiling of the Tumor Microenvironment
    Sixian You, Eric J. Chaney, Haohua Tu, Yi Sun, Saurabh Sinha and Stephen A. Boppart
    Cancer Res May 1 2021 81 (9) 2534-2544; DOI:10.1158/0008-5472.CAN-20-3124

    The proposed computational framework allows label-free microscopic analysis that quantifies the complexity and heterogeneity of the tumor microenvironment and opens possibilities for better characterization and utilization of the evolving cancer landscape.

  • A Spatial and Functional Interaction of a Heterotetramer Survivin–DNA-PKcs Complex in DNA Damage Response
    Molecular Cell Biology
    A Spatial and Functional Interaction of a Heterotetramer Survivin–DNA-PKcs Complex in DNA Damage Response
    Ömer Güllülü, Stephanie Hehlgans, Benjamin E. Mayer, Ines Gößner, Chrysi Petraki, Melanie Hoffmann, Maximilian J. Dombrowsky, Patrick Kunzmann, Kay Hamacher, Klaus Strebhardt, Emmanouil Fokas, Claus Rödel, Christian Münch and Franz Rödel
    Cancer Res May 1 2021 81 (9) 2304-2317; DOI:10.1158/0008-5472.CAN-20-2931

    These findings provide insight into survivin-mediated regulation of DNA–PKcs kinase and broaden our knowledge of the impact of survivin in modulating the cellular radiation response.

  • Population and Prevention Science
    Genetic Variants Associated with Therapy-Related Cardiomyopathy among Childhood Cancer Survivors of African Ancestry
    Yadav Sapkota, Na Qin, Matthew J. Ehrhardt, Zhaoming Wang, Yan Chen, Carmen L. Wilson, Jeremie Estepp, Parul Rai, Jane S. Hankins, Paul W. Burridge, John L. Jefferies, Jinghui Zhang, Melissa M. Hudson, Leslie L. Robison, Gregory T. Armstrong, Daniel A. Mulrooney and Yutaka Yasui
    Cancer Res May 1 2021 81 (9) 2556-2565; DOI:10.1158/0008-5472.CAN-20-2675

    Childhood cancer survivors of African ancestry are at higher risk of cardiomyopathy than those of European ancestry, and a novel locus at 1p13.2 is associated with therapy-related cardiomyopathy specifically in African-American survivors.

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