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From the Current Issue

  • Translational Science
    Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis
    Maryam Khelil, Heather Griffin, Maaike C.G. Bleeker, Renske D.M. Steenbergen, Ke Zheng, Taylor Saunders-Wood, Sanne Samuels, Jossie Rotman, Wim Vos, Brendy E. van den Akker, Renée X. de Menezes, Gemma G. Kenter, John Doorbar and Ekaterina S. Jordanova
    Cancer Res April 1 2021 81 (7) 1909-1921; DOI:10.1158/0008-5472.CAN-20-1996

    This study investigates cervical cancer cell-of-origin populations and describes a DLL-Notch1 phenotype that is associated with disease prognosis and that might help identify cells that are susceptible to HPV-induced carcinogenesis.

  • Molecular Cell Biology
    Glia-Selective Deletion of Complement C1q Prevents Radiation-Induced Cognitive Deficits and Neuroinflammation
    Mineh Markarian, Robert P. Krattli Jr, Jabra D. Baddour, Leila Alikhani, Erich Giedzinski, Manal T. Usmani, Anshu Agrawal, Janet E. Baulch, Andrea J. Tenner and Munjal M. Acharya
    Cancer Res April 1 2021 81 (7) 1732-1744; DOI:10.1158/0008-5472.CAN-20-2565

    Clinically-relevant radiotherapy induces aberrant complement activation, leading to brain injury. Microglia-selective genetic deletion of CNS complement C1q ameliorates radiation-induced cognitive impairments, synaptic loss, and neuroinflammation, highlighting the potential for C1q as a novel therapeutic target.

  • Genome and Epigenome
    A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility
    Nima C. Emami, Taylor B. Cavazos, Sara R. Rashkin, Clinton L. Cario, Rebecca E. Graff, Caroline G. Tai, Joel A. Mefford, Linda Kachuri, Eunice Wan, Simon Wong, David Aaronson, Joseph Presti, Laurel A. Habel, Jun Shan, Dilrini K. Ranatunga, Chun R. Chao, Nirupa R. Ghai, Eric Jorgenson, Lori C. Sakoda, Mark N. Kvale, Pui-Yan Kwok, Catherine Schaefer, Neil Risch, Thomas J. Hoffmann, Stephen K. Van Den Eeden and John S. Witte
    Cancer Res April 1 2021 81 (7) 1695-1703; DOI:10.1158/0008-5472.CAN-20-2635

    This study maps the biological relationships between diverse risk factors for prostate cancer, integrating different functional datasets to interpret and model genome-wide data from over 200,000 men with and without prostate cancer.

  • Tumor Biology and Immunology
    Pan-Cancer Analysis of Ligand–Receptor Cross-talk in the Tumor Microenvironment
    Umesh Ghoshdastider, Neha Rohatgi, Marjan Mojtabavi Naeini, Probhonjon Baruah, Egor Revkov, Yu Amanda Guo, Simone Rizzetto, Angeline M.L. Wong, Sundar Solai, Tin T. Nguyen, Joe Poh Sheng Yeong, Jabed Iqbal, Puay Hoon Tan, Balram Chowbay, Ramanuj Dasgupta and Anders J. Skanderup
    Cancer Res April 1 2021 81 (7) 1802-1812; DOI:10.1158/0008-5472.CAN-20-2352

    This study provides deconvoluted bulk tumor transcriptomes across multiple cancer types to infer cross-talk in the tumor microenvironment.

See the Table of Contents

Recent Reviews

  • Review | AuthorChoice
    Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers
    Adam J. Wolpaw, Richard Bayliss, Gabriele Büchel, Chi V. Dang, Martin Eilers, W. Clay Gustafson, Gwenn H. Hansen, Natalia Jura, Stefan Knapp, Mark A. Lemmon, David Levens, John M. Maris, Ronen Marmorstein, Steven J. Metallo, Julie R. Park, Linda Z. Penn, Michael Rape, Martine F. Roussel, Kevan M. Shokat, William P. Tansey, Kliment A. Verba, Seychelle M. Vos, William A. Weiss, Elmar Wolf and Yaël P. Mossé
    Cancer Res April 1 2021 81 (7) 1627-1632; DOI:10.1158/0008-5472.CAN-20-3108

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