Summary
6-Thioguanine was found to be rapidly absorbed from the blood stream by the tissues and rapidly eliminated in the urine. In tumor it was converted primarily to nucleotides; in intestine, liver, and bone marrow, approximately equal amounts of nucleotides and of thiouric acid were found. Tissue distribution and metabolites found with different times and doses were reported.
Footnotes
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↵* A preliminary report has appeared (11).
This research was supported in part by United States Public Health Service Grant No. C2491 and in part by the Alexander and Margaret Stewart Fund.
- Received May 26, 1958.
- ©1958 American Association for Cancer Research.
October 1958
Volume 18, Issue 9
Volume 18, Issue 9
The Metabolism of 6-Thioguanine in Normal and Neoplastic Tissues
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