Summary
A review is presented of the clinical applications of 5-fluorouracil (5-FU) and 5-fluoro-2′-deoxyuridine (5-FUDR). This includes biochemical and pharmacological studies of the drugs in cancer patients and emphasizes particularly their distribution and metabolic fate. A critical review of the literature on the chemotherapeutic trials of these compounds has been made, and it is concluded that 5-FU and 5-FUDR are clinically useful in the palliation of patients suffering from advanced cancer. Tumors of the breast and gastrointestinal tract are the most responsive to these drugs.
Footnotes
- ©1963 American Association for Cancer Research.
September 1963
Volume 23, Issue 8 Part 1
Volume 23, Issue 8 Part 1
Experimental and Clinical Use of Fluorinated Pyrimidines in Cancer Chemotherapy
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