Abstract
The effects of sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate on carcinogen-induced neoplasia were studied in experiments in which the test compound was fed starting 1 week following completion of carcinogen administrations. Under these conditions, all three test compounds exerted an inhibitory effect on the occurrence of 7,12-dimethylbenz(a)anthracene-induced neoplasia of the breast of Sprague-Dawley rats. In a second experiment model, sodium cyanate inhibited the occurrence of 1,2-dimethylhydrazine-induced neoplasia of the large bowel of female CF-1 mice. Thus, a new group of compounds has been identified which has inhibitory capacities against neoplasia when given subsequent to carcinogen exposure.
Footnotes
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↵1 Supported by USPHS Research Grants CA-15638 through the National Large Bowel Cancer Project and CA-14146, both from the National Cancer Institute.
- Received February 13, 1981.
- Accepted April 22, 1981.
- ©1981 American Association for Cancer Research.
Volume 41, Issue 8
