Abstract
Mice given injections of high antileukemic doses of cyclophosphamide lost the capacity to generate cytotoxic T-cells in vivo to allogeneic tumor cells. These low responses were not due to the elimination of cytotoxic T-lymphocyte precursors because normal cytotoxic responses were obtained in vivo after cyclophosphamide treatment by injection of helper factor derived from mixed-lymphocyte-culture supernatants.
Footnotes
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↵1 This work was supported by National Cancer Institute Grants CA-26335, CA-26508, and CA-16271.
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↵2 To whom requests for reprints should be addressed.
- Received March 23, 1981.
- Accepted June 8, 1981.
- ©1981 American Association for Cancer Research.
September 1981
Volume 41, Issue 9 Part 1
Volume 41, Issue 9 Part 1
Recovery of the in Vivo Cytotoxic T-Cell Response in Cyclophosphamide-treated Mice by Injection of Mixed-Lymphocyte-Culture Supernatants
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