Abstract
A series of human germ cell-derived tumors were examined for the presence of nucleoli which persist through mitosis. Embryonal carcinomas, seminomas, and the cytotrophoblasts of choriocarcinomas had persistent nucleoli in more than 70% of mitoses. The differentiated cells derived from embryonal carcinomas, endodermal sinus tumors, and the more differentiated elements of choriocarcinomas only rarely had persistent nucleoli. These nucleoli appeared to remain transcriptionally active.
Footnotes
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↵1 This work was supported by Grants CA-09157, CA-16030, CA-15823, and CA-13419 from the National Cancer Institute and PCM 76-81019 from the National Science Foundation.
- Received May 4, 1981.
- Accepted June 25, 1981.
- ©1981 American Association for Cancer Research.
September 1981
Volume 41, Issue 9 Part 1
Volume 41, Issue 9 Part 1
Continued Presence of Nucleoli in Human Germ Cell Tumors during Mitosis
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