Abstract
Some calcium antagonists and calmodulin inhibitors enhance the intracellular levels of vincristine and Adriamycin in vincristine- and Adriamycin-resistant P388 leukemia cells by inhibiting their outward transport. The high intracellular drug accumulation was directly related to the enhancement of the cytotoxicity of the antitumor agents, and the vincristine and Adriamycin resistance in these cells was circumvented.
Footnotes
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↵1 This work was supported by Grants-in Aid for Cancer Research from the Ministry of Education, Science, and Culture (56010019) and from the Ministry of Health and Welfare (54–5), Japan.
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↵2 Recipient of an Award from Society for Promotion of Cancer Research, Japan. To whom requests for reprints should be addressed.
- Received December 4, 1981.
- Accepted August 5, 1982.
- ©1982 American Association for Cancer Research.
November 1982
Volume 42, Issue 11
Volume 42, Issue 11
Increased Accumulation of Vincristine and Adriamycin in Drug-resistant P388 Tumor Cells following Incubation with Calcium Antagonists and Calmodulin Inhibitors
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