Abstract
Synthetic and analytical approaches were used to characterize the tumor-localizing components of the porphyrin preparation, hematoporphyrin derivative. From studies involving aqueous and nonaqueous gel exclusion and reverse-phase chromatography, we conclude that localization is mediated by hematoporphyrin derivative components which are among the most hydrophobic in the preparation. This apparent hydrophobicity may derive from hydrogen-bonding phenomena, rather than from absence of hydrophilic functional groups.
Footnotes
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↵1 Supported by Grant CA 23378 from the National Cancer Institute, NIH, Department of Health and Human Services.
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↵2 To whom requests for reprints should be addressed.
- Received July 22, 1982.
- Accepted January 28, 1983.
- ©1983 American Association for Cancer Research.
May 1983
Volume 43, Issue 5
Volume 43, Issue 5
Tumor-localizing Components of the Porphyrin Preparation Hematoporphyrin Derivative
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