Abstract
The effect of tetragastrin on the incidence and histology of colonic tumors induced by intrarectal instillation of N-methyl-N′-nitro-N-nitrosoguanidine was investigated in Wistar rats. Prolonged administration of tetragastrin in depot form during and after treatment with N-methyl-N′-nitro-N-nitrosoguanidine resulted in a significant reduction in the incidence of colonic tumors in Experimental Week 35. Histological examinations showed that, unlike the well-differentiated adenocarcinomas with a typical glandular pattern in control groups, the adenocarcinomas that developed in rats treated with tetragastrin had high mucin-producing activity.
Footnotes
-
↵1 To whom requests for reprints should be addressed.
- Received August 3, 1982.
- Accepted January 26, 1983.
- ©1983 American Association for Cancer Research.
May 1983
Volume 43, Issue 5
Volume 43, Issue 5
Effect of Prolonged Administration of Gastrin on Experimental Carcinogenesis in Rat Colon Induced by Intrarectal Instillation of N-Methyl-N′-nitro-N-nitrosoguanidine
Jump to section
Advertisement