Abstract
The Epstein-Barr virus (EBV)-specific leukocyte migration inhibition (LMI) reaction was used to detect EBV antigens in human tumor biopsies in parallel with nucleic acid hybridization for EBV DNA. None of six EBV DNA-negative tumors gave any significant LMI reaction. Fourteen of 17 EBV DNA-positive tumors gave a significant difference between the migration of leukocytes from EBV-seropositive versus -seronegative donors. One tumor gave a borderline reaction. The two LMI-negatives in this group had only a marginal EBV DNA content. It is suggested that the EBV-specific LMI test may be useful for detecting EBV genomes in tissue and tumor extracts.
Footnotes
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↵1 This study was supported by NIH Grant 1RO1CA28380-02 and 1R01CA33324-01 by the Swedish Cancer Society.
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↵2 Recipient of a grant from the Cancer Research Institute, Inc., New York, N. Y.
- Received November 29, 1982.
- Accepted February 2, 1983.
- ©1983 American Association for Cancer Research.
Volume 43, Issue 5
