Table of Contents

Articles

• Editorial

  Perspectives in Cancer Research

  P. N. Magee

  Cancer Res July 1 1983 43 (7) 3033-3033;

  
  
• Perspectives in Cancer Research

  Role of Retinoids in Differentiation and Carcinogenesis

  Michael B. Spom and Anita B. Roberts

  Cancer Res July 1 1983 43 (7) 3034-3040;

  
  
• Basic Sciences

  Effect of Hyperglycemia on Thermochemotherapy of a Spontaneous Murine Fibrosarcoma

  M. Urano and M. S. Kim

  Cancer Res July 1 1983 43 (7) 3041-3044;

  
  
• Basic Sciences

  Inhibition of 7-Bromomethylbenz[a]anthracene-promoted Mouse Skin Tumor Formation by Retinoic Acid and Dexamethasone

  Ajit K. Verma, C. T. Garcia, Curtis L. Ashendel and R. K. Boutwell

  Cancer Res July 1 1983 43 (7) 3045-3049;

  
  
• Basic Sciences

  Effect of Tumor Size on S-2-(3-Aminopropylamino)ethylphosphorothioic Acid and Misonidazole Alteration of Tumor Response to Cyclophosphamide

  Luka Milas, Hisao Ito and Nancy Hunter

  Cancer Res July 1 1983 43 (7) 3050-3056;

  
  
• Basic Sciences

  Generation of Phenotypic Diversity in the B16 Mouse Melanoma Relative to Spontaneous Metastasis

  Christopher W. Stackpole

  Cancer Res July 1 1983 43 (7) 3057-3065;

  
  
• Basic Sciences

  Human NH₂ Terminal of Pro-opiomelanocortin as a Potential Marker for Pulmonary Carcinoma

  John S. D. Chan, Nabil G. Seidah and Michel Chrétien

  Cancer Res July 1 1983 43 (7) 3066-3069;

  
  
• Basic Sciences

  Potentiation of DNA-reactive Antineoplastic Agents and Protection against S-Phase-specific Agents by Anguidine in Chinese Hamster Ovary Cells

  Robert Hromas, Barthel Barlogie, Douglas Swartzendruber and Benjamin Drewinko

  Cancer Res July 1 1983 43 (7) 3070-3073;

  
  
• Basic Sciences

  Uptake, Initial Effects, and Chemotherapeutic Efficacy of Harringtonine in Murine Leukemic Cells Sensitive and Resistant to Vincristine and Other Chemotherapeutic Agents

  Ting-Chao Chou, Franz A. Schmid, Aaron Feinberg, Frederick S. Philips and Jui Han

  Cancer Res July 1 1983 43 (7) 3074-3079;

  
  
• Basic Sciences

  Metabolism of Acrylonitrile by Isolated Rat Hepatocytes

  Lee E. Geiger, Lora L. Hogy and F. Peter Guengerich

  Cancer Res July 1 1983 43 (7) 3080-3087;

  
  
• Basic Sciences

  Chemotherapy and Radiation Therapy of Human Medulloblastoma in Athymic Nude Mice

  Henry S. Friedman, S. Clifford Schold Jr., Mahesh Varia and Darell D. Bigner

  Cancer Res July 1 1983 43 (7) 3088-3093;

  
  
• Basic Sciences

  Characterization and Quantitation of Antiestrogen Binding Sites in Estrogen Receptor-positive and -negative Human Breast Cancer Cell Lines

  Margaret Ann Miller and Benita S. Katzenellenbogen

  Cancer Res July 1 1983 43 (7) 3094-3100;

  
  
• Basic Sciences

  Tumoricidal Effects of Sodium Hexachloroiridate on an Ascitic Tumor in Mice

  Gerald M. Kolodny and Christopher Rose

  Cancer Res July 1 1983 43 (7) 3101-3103;

  
  
• Basic Sciences

  Effect of 3-Aminobenzamide on the Rate of Ligation during Repair of Alkylated DNA in Human Fibroblasts

  William F. Morgan and James E. Cleaver

  Cancer Res July 1 1983 43 (7) 3104-3107;

  
  
• Basic Sciences

  Experimental Hyperthermic Isolation-Perfusion Using cis-Diamminedichloroplatinum(II)

  Alan G. Wile, Maurice Y. Nahabedian, Donald A. Plumley, J. Edward Guilmette and G. Robert Mason

  Cancer Res July 1 1983 43 (7) 3108-3111;

  
  
• Basic Sciences

  Some Advantages of Curing Mice Bearing a Large Subcutaneous MOPC-315 Tumor with a Low Dose Rather Than a High Dose of Cyclophosphamide

  Margalit B. Mokyr and Sheldon Dray

  Cancer Res July 1 1983 43 (7) 3112-3119;

  
  
• Basic Sciences

  Role of the Acetylation Polymorphism in Determining Susceptibility of Cultured Rabbit Hepatocytes to DNA Damage by Aromatic Amines

  Charlene A. McQueen, Carol J. Maslansky and Gary M. Williams

  Cancer Res July 1 1983 43 (7) 3120-3123;

  
  
• Basic Sciences

  Effect of Hyperthermia on the Survival of Normal Human Peripheral Blood Mononuclear Cells

  Shyam S. Agarwal, Edward J. Katz and Lawrence A. Loeb

  Cancer Res July 1 1983 43 (7) 3124-3126;

  
  
• Basic Sciences

  Absence in Glucocorticoid-resistant Mouse Lymphoma P1798 of a Glucocorticoid Receptor Domain Responsible for Biological Effects

  Sam Okret, Yee-Wan Stevens, Jan Carlstedt-Duke, Örjan Wrange, Jan-Åke Gustafsson and John Stevens

  Cancer Res July 1 1983 43 (7) 3127-3131;

  
  
• Basic Sciences

  Identification and Mutagenicity of Metabolites of 1-Nitropyrene Formed by Rat Liver

  Karam El-Bayoumy and Stephen S. Hecht

  Cancer Res July 1 1983 43 (7) 3132-3137;

  
  
• Basic Sciences

  Influence of Heat on the Intracellular Uptake and Radiosensitization of 2-Nitroimidazole Hypoxic Cell Sensitizers in Vitro

  Dennis M. Brown, Mark S. Cohen, Robert H. Sagerman, Ricardo Gonzalez-Mendez, George M. Hahn and J. Martin Brown

  Cancer Res July 1 1983 43 (7) 3138-3142;

  
  
• Basic Sciences

  A Fast and Convenient Method for Determining Estrogen Receptor Using Rabbit Uterus as a Standard

  J. Mukharji, N. Y. Zachariah, Z. H. Chakmakjian and G. J. Race

  Cancer Res July 1 1983 43 (7) 3143-3146;

  
  
• Basic Sciences

  Comparison of in Vitro Methods for Assessing Cytotoxic Activity against Two Pancreatic Adenocarcinoma Cell Lines

  Barbara K. Chang

  Cancer Res July 1 1983 43 (7) 3147-3149;

  
  
• Basic Sciences

  Nuclear Thyroid Hormone Receptors, α-Glycerophosphate Dehydrogenases, and Malic Enzyme in N-Nitrosomethylurea-induced Rat Mammary Tumors

  Frank J. Ruzicka and David P. Rose

  Cancer Res July 1 1983 43 (7) 3150-3154;

  
  
• Basic Sciences

  Monoclonal Antibodies to Human Melanoma-associated Antigens: An Amplified Enzyme-linked Immunosorbent Assay for the Detection of Antigen, Antibody, and Immune Complexes

  Alton C. Morgan Jr. and Robert F. Mclntyre

  Cancer Res July 1 1983 43 (7) 3155-3159;

  
  
• Basic Sciences

  Low Oral Bioavailability of Hexamethylmelamine in the Rat Due to Simultaneous Hepatic and Intestinal Metabolism

  Pierre J. M. Klippert, Abram Hulshoff, Marie-José J. Mingels, Gerard Hofman and Jan Noordhoek

  Cancer Res July 1 1983 43 (7) 3160-3164;

  
  
• Basic Sciences

  Effects of Ultraviolet-visible Irradiation in the Presence of Melanin Isolated from Human Black or Red Hair upon Ehrlich Ascites Carcinoma Cells

  I. Aravindakshan Menon, Surujdeen Persad, Narendranath S. Ranadive and Herbert F. Haberman

  Cancer Res July 1 1983 43 (7) 3165-3169;

  
  
• Basic Sciences

  Prolactin-like Activity of Antiprolactin Receptor Antibodies in Rat Mammary Tumor Explants

  Marc Edery, Jean Djiane, Louis-Marie Houdebine and Paul A. Kelly

  Cancer Res July 1 1983 43 (7) 3170-3174;

  
  
• Basic Sciences

  Mechanism of Sensitization of Chinese Hamster Ovary Cells to Melphalan by Hypoxic Treatment with Misonidazole

  Yvonne C. Taylor, James W. Evans and J. Martin Brown

  Cancer Res July 1 1983 43 (7) 3175-3181;

  
  
• Basic Sciences

  Use of Uridine Rescue to Enhance the Antitumor Selectivity of 5-Fluorouracil

  Philip Klubes and Ingeborg Cerna

  Cancer Res July 1 1983 43 (7) 3182-3186;

  
  
• Basic Sciences

  Systemic Lidocaine Enhancement of Hyperthermia-induced Tumor Regression in Transplantable Murine Tumor Models

  H. Ian Robins, Warren H. Dennis, James S. Slattery, Thomas A. Lange and Milton B. Yatvin

  Cancer Res July 1 1983 43 (7) 3187-3191;

  
  
• Basic Sciences

  Combination Chemotherapy Involving α-Difluoromethylornithine and 1-β-d-Arabinofuranosylcytosine in Murine L1210 Leukemia

  Nellikunja J. Prakash and Prasad S. Sunkara

  Cancer Res July 1 1983 43 (7) 3192-3196;

  
  
• Basic Sciences

  Role of Lipid Transfer Proteins in the Abnormal Lipid Content of Morris Hepatoma Mitochondria and Microsomes

  Richard C. Crain, Ronald W. Clark and Brian E. Harvey

  Cancer Res July 1 1983 43 (7) 3197-3202;

  
  
• Basic Sciences

  Modulation of Involucrin and Envelope Competence in Human Keratinocytes by Hydrocortisone, Retinyl Acetate, and Growth Arrest

  Polly R. Cline and Robert H. Rice

  Cancer Res July 1 1983 43 (7) 3203-3207;

  
  
• Basic Sciences

  Effects of Combination Estrogen:Cyclophosphamide Treatment on the Growth of the MXT Transplantable Mammary Tumor in the Mouse

  B. M. Markaverich, D. Medina and J. H. Clark

  Cancer Res July 1 1983 43 (7) 3208-3211;

  
  
• Basic Sciences

  Involvement of both Syn- and Anti-Dihydrodiol-Epoxides in the Binding of 7,12-Dimethylbenz(a)anthracene to DNA in Mouse Embryo Cell Cultures

  Josef T. Sawicki, Robert C. Moschel and Anthony Dipple

  Cancer Res July 1 1983 43 (7) 3212-3218;

  
  
• Basic Sciences

  Divergent Effects of Retinoids on Pancreatic and Liver Carcinogenesis in Azaserine-treated Rats

  Daniel S. Longnecker, Elna T. Kuhlmann and Thomas J. Curphey

  Cancer Res July 1 1983 43 (7) 3219-3225;

  
  
• Basic Sciences

  Effects of Four Retinoids in N-Nitrosobis(2-oxopropyl)amine-treated Hamsters

  Daniel S. Longnecker, Elna T. Kuhlmann and Thomas J. Curphey

  Cancer Res July 1 1983 43 (7) 3226-3230;

  
  
• Basic Sciences

  Interaction of Ultrasonic Hyperthermia with Two Alkylating Agents in a Murine Bladder Tumor

  Frank W. Longo, Philip Tomashefsky, Bermard D. Rivin and Myron Tannenbaum

  Cancer Res July 1 1983 43 (7) 3231-3235;

  
  
• Basic Sciences

  Weak Promotion of C3H/10T½ Cell Transformation by Repeated Treatments with Formaldehyde

  Janet H. Frazelle, Diane J. Abernethy and Craig J. Boreiko

  Cancer Res July 1 1983 43 (7) 3236-3239;

  
  
• Basic Sciences

  Thermal Survival Characteristics of Cell Subpopulations Isolated from a Heterogeneous Human Colon Tumor

  John T. Leith, Philip Heyman, J. Keith DeWyngaert, Daniel L. Dexter, Paul Calabresi and Arvin S. Glicksman

  Cancer Res July 1 1983 43 (7) 3240-3246;

  
  
• Basic Sciences

  O⁶-Methylguanine-DNA Methyltransferase of Human Lymphoid Cells: Structural and Kinetic Properties and Absence in Repair-deficient Cells

  Adrian L. Harris, Peter Karran and Tomas Lindahl

  Cancer Res July 1 1983 43 (7) 3247-3252;

  
  
• Basic Sciences

  Murine Metabolism and Disposition of Iron:Adriamycin Complexes

  Merrill J. Egorin, Ronald E. Clawson, Louis A. Ross, Rosalind D. Friedman, Steven D. Reich, Avrom Pollak and Nicholas R. Bachur

  Cancer Res July 1 1983 43 (7) 3253-3262;

  
  
• Basic Sciences

  Loss of Tumorigenicity of Lewis Lung Carcinoma on the Chorioallantoic Membrane of the Chick Embryo

  D. Belin and L. Ossowski

  Cancer Res July 1 1983 43 (7) 3263-3269;

  
  
• Basic Sciences

  Direct and Indirect Clastogenic Activity of Anthracenedione in Chinese Hamster Ovary Cells

  Larry J. Rosenberg and Walter N. Hittelman

  Cancer Res July 1 1983 43 (7) 3270-3275;

  
  
• Basic Sciences

  Fluorescent Nitroheterocycles for Identifying Hypoxic Cells

  Peggy L. Olive and Ralph E. Durand

  Cancer Res July 1 1983 43 (7) 3276-3280;

  
  
• Basic Sciences

  Stimulation of Increased Capillary Endothelial Cell Motility by Chondrosarcoma Cell-derived Factors

  J. Azizkhan, R. Sullivan, R. Azizkhan, B. R. Zetter and M. Klagsbrun

  Cancer Res July 1 1983 43 (7) 3281-3286;

  
  
• Basic Sciences

  Clonal Chromosome Changes in Stimulated Lymphocytes of Untreated Human B-Cell Leukemias

  Naoki Sadamori, Tin Han, Jun Minowada, Sei-ichi Matsui and Avery A. Sandberg

  Cancer Res July 1 1983 43 (7) 3287-3291;

  
  
• Basic Sciences

  Organ-specific Promoting Effect of Phenobarbital and Saccharin in Induction of Thyroid, Liver, and Urinary Bladder Tumors in Rats after Initiation with N-Nitrosomethylurea

  Hiroyuki Tsuda, Shoji Fukushima, Katsumi Imaida, Yasushi Kurata and Nobuyuki Ito

  Cancer Res July 1 1983 43 (7) 3292-3296;

  
  
• Basic Sciences

  Comparison of Soluble Protein Kinases from Normal Rat Prostates and Prostatic Dunning Tumors

  Leland W. K. Chung and Karen Breitweiser

  Cancer Res July 1 1983 43 (7) 3297-3304;

  
  
• Basic Sciences

  Immunocytochemical Demonstration of Hormonally Regulable Casein in Tumors Produced by a Rat Mammary Stem Cell Line

  Philip S. Rudland, Christine M. Hughes, Anna C. Twiston Davies and Michael J. Warburton

  Cancer Res July 1 1983 43 (7) 3305-3309;

  
  
• Basic Sciences

  Nononcogenic Hormone-independent Alveoli Produced by Carcinogens in Cultured Mouse Mammary Glands

  Frederick V. Schaefer, Quentin J. Tonelli, Michael S. Dickens, R. Philip Custer and Sam Sorof

  Cancer Res July 1 1983 43 (7) 3310-3315;

  
  
• Basic Sciences

  O⁶-Methylguanine Removal by Competent and Incompetent Human Lymphoblastoid Lines from the Same Male Individual

  Robert M. Sklar and Bernard S. Strauss

  Cancer Res July 1 1983 43 (7) 3316-3320;

  
  
• Basic Sciences

  Activation of Cyclic Adenosine 3′:5′-Monophosphate-dependent Protein Kinase in H35 Hepatoma and Chinese Hamster Ovary Cells by a Phorbol Ester Tumor Promoter

  Craig V. Byus, James M. Trevillyan, Leslie J. Cavit and William H. Fletcher

  Cancer Res July 1 1983 43 (7) 3321-3326;

  
  
• Basic Sciences

  Demonstration of Complex Antigenic Heterogeneity in a Human Glioma Cell Line and Eight Derived Clones by Specific Monoclonal Antibodies

  Carol J. Wikstrand, Sandra H. Bigner and Darell D. Bigner

  Cancer Res July 1 1983 43 (7) 3327-3334;

  
  
• Basic Sciences

  Isolation and Characterization of Endoplasmic Reticulum and Golgi Apparatus from Hepatocyte Nodules in Male Wistar Rats

  Lennart C. Eriksson, Ulla-Britta Torndal and Göran N. Andersson

  Cancer Res July 1 1983 43 (7) 3335-3347;

  
  
• Basic Sciences

  Alterations of Human Endometrial Stromal Cells Produced by N-Methyl-N′-nitro-N-nitrosoguanidine

  B. Hugh Dorman, Jill M. Siegfried and David G. Kaufman

  Cancer Res July 1 1983 43 (7) 3348-3357;

  
  
• Basic Sciences

  Estimation of the Number of Genes Specifying the Heavy Chain of Mouse Thymus Leukemia Antigens

  Ryszard Slomski, Christine L. Martens and Edward P. Cohen

  Cancer Res July 1 1983 43 (7) 3358-3361;

  
  
• Basic Sciences

  Regional Measurements of Blood Flow in Experimental RG-2 Rat Gliomas

  Dennis R. Groothuis, Joseph F. Pasternak, Joan M. Fischer, Ronald G. Blasberg, Darell D. Bigner and Nicholas A. Vick

  Cancer Res July 1 1983 43 (7) 3362-3367;

  
  
• Basic Sciences

  Regional Measurements of Blood-to-Tissue Transport in Experimental RG-2 Rat Gliomas

  Dennis R. Groothuis, Joan M. Fischer, Joseph F. Pasternak, Ronald G. Blasberg, Nicholas A. Vick and Darell D. Bigner

  Cancer Res July 1 1983 43 (7) 3368-3373;

  
  
• Basic Sciences

  Effect of Size on Portal Circulation of Hepatic Nodules from Carcinogen-treated Rats

  James G. Conway, James A. Popp, Sungchul Ji and Ronald G. Thurman

  Cancer Res July 1 1983 43 (7) 3374-3378;

  
  
• Basic Sciences

  Characterization of a Differentiated Cat Melanoma Cell Line

  Suraiya Rasheed

  Cancer Res July 1 1983 43 (7) 3379-3384;

  
  
• Basic Sciences

  Calcium Modulation of Phorbol Ester-induced Alterations in Murine Macrophage Morphology

  Bonita M. Smith, Robert J. Sturm and Richard A. Carchman

  Cancer Res July 1 1983 43 (7) 3385-3391;

  
  
• Basic Sciences

  Treatment of Mouse Mammary Tumors Using Combined Hyperthermia and Ischemia

  Geraldine M. Baker and Eric A. Wright

  Cancer Res July 1 1983 43 (7) 3392-3397;

  
  
• Basic Sciences

  Immunoprecipitation as a Tool for Studying Humoral Immunity of Natural and Experimental Hosts of Herpesvirus saimiri

  Susanne Modrow, Helga Schmidt and Hans Wolf

  Cancer Res July 1 1983 43 (7) 3398-3402;

  
  
• Clinical Investigations

  Multivariate Analysis of Prognostic Variables in Patients with Metastatic Testicular Cancer

  George J. Bosl, Nancy L. Geller, Constance Cirrincione, Nicholas J. Vogelzang, B. J. Kennedy, Willet F. Whitmore Jr., Davor Vugrin, Howard Scher, Jerome Nisselbaum and Robert B. Golbery

  Cancer Res July 1 1983 43 (7) 3403-3407;

  
  
• Clinical Investigations

  Paradoxical Effects Associated with Supranormal Urinary Testosterone Excretion in Premenopausal Women with Breast Cancer: Increased Risk of Postmastectomy Recurrence and Higher Remission Rate after Ovariectomy

  Giorgio Secreto and Barnett Zumoff

  Cancer Res July 1 1983 43 (7) 3408-3411;

  
  
• Clinical Investigations

  Pharmacokinetics of N⁴-Behenoyl-1-β-d-arabinofuranosylcytosine in Patients with Acute Leukemia

  Takanori Ueda, Toru Nakamura, Seisho Ando, Daizaburo Kagawa, Masataka Sasada, Haruto Uchino, Ikuo Johno and Yuichi Akiyama

  Cancer Res July 1 1983 43 (7) 3412-3416;

  
  
• Clinical Investigations

  Plasma Pharmacokinetics of Adriamycin and Adriamycinol: Implications for the Design of in Vitro Experiments and Treatment Protocols

  Raymond F. Greene, Jerry M. Collins, Jean F. Jenkins, James L. Speyer and Charles E. Myers

  Cancer Res July 1 1983 43 (7) 3417-3421;

  
  
• Clinical Investigations

  Human Pharmacokinetics of a New Acridine Derivative, 4′-(9-Acridinylamino)methanesulfon-m-anisidide (NSC 249992)

  Stephen W. Hall, Jacqueline Friedman, Sewa S. Legha, Robert S. Benjamin, Jordan U. Gutterman and Ti Li Loo

  Cancer Res July 1 1983 43 (7) 3422-3426;

  
  
• Clinical Investigations

  Patterned Distribution of Metastases from Malignant Melanoma in Humans

  S. M. de la Monte, G. William Moore and Grover M. Hutchins

  Cancer Res July 1 1983 43 (7) 3427-3433;

  
  
• Clinical Investigations

  In Vivo Drug Sensitivity Assay of Clonogenic Human Melanoma Cells and Correlation with Treatment Outcome

  John M. Kirkwood and John C. Marsh

  Cancer Res July 1 1983 43 (7) 3434-3440;

  
  
• Clinical Investigations

  Aberration of Poly(Adenosine Diphosphate-Ribose) Metabolism in Human Colon Adenomatous Polyps and Cancers

  Kiyoshi Hirai, Kunihiro Ueda and Osamu Hayaishi

  Cancer Res July 1 1983 43 (7) 3441-3446;

  
  
• Clinical Investigations

  Comparison of Electron Paramagnetic Resonance and Atomic Absorption Serum Copper Measurements in Human Normal Control and Cancer Patients

  F. W. Kleinhans, Samuel C. Kline, William M. Dugan Jr. and James G. Williams

  Cancer Res July 1 1983 43 (7) 3447-3450;

  
  
• Clinical Investigations

  S-Adenosylhomocysteine Catabolism and Basis for Acquired Resistance during Treatment of T-Cell Acute Lymphoblastic Leukemia with 2′-Deoxycoformycin Alone and in Combination with 9-β-d-Arabinofuranosyladenine

  Michael S. Hershfield, Nicholas M. Kredich, Charles A. Koller, Beverly S. Mitchell, Joanne Kurtzberg, Thomas R. Kinney and John M. Falletta

  Cancer Res July 1 1983 43 (7) 3451-3458;

  
  
• Articles

  Announcements

  Cancer Res July 1 1983 43 (7) 3459-3460;

  
  
• Errata

  Drug and Hormone Sensitivity of Estrogen Receptor-positive and -negative Human Breast Cancer Cells in Vitro

  Cancer Res July 1 1983 43 (7) 3460-3460;

  
  
• Errata

  Reliable Stereological Method for Estimating the Number of Microscopic Hepatocellular Foci from Their Transections

  Cancer Res July 1 1983 43 (7) 3460-3460;

  
  
• Errata

  Circulating Levels of Feline Leukemia and Sarcoma Viruses and Fibrosarcoma Regression in Persistently Viremic Cats

  Cancer Res July 1 1983 43 (7) 3460-3460;

  
  
• Errata

  Toxicity of Aziridinylbenzoquinone for Aerobic and Hypoxic Cells of a Transplanted Mouse Mammary Tumor and Interaction of the Drug with Radiation and Adriamycin

  Cancer Res July 1 1983 43 (7) 3460-3460;

  
  
• Obituary

  Solomon Spiegelman

  Richard Axel

  Cancer Res July 1 1983 43 (7) 3461-3461;

  
  
• Articles

  Books Received

  Cancer Res July 1 1983 43 (7) 3462-3462;

  
  
• Articles

  Books Received

  Cancer Res July 1 1983 43 (7) 3462-3462;

  
  
• Articles

  New Journal

  Cancer Res July 1 1983 43 (7) 3462-3462;