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Basic Sciences

Ductal Metaplasia of Human Exocrine Pancreas and Its Association with Carcinoma

Ismail Parsa, Daniel S. Longnecker, Dante G. Scarpelli, Parviz Pour, Janardan K. Reddy and Martin Lefkowitz
Ismail Parsa
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Daniel S. Longnecker
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Dante G. Scarpelli
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Parviz Pour
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Janardan K. Reddy
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Martin Lefkowitz
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DOI:  Published March 1985
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Abstract

Monoclonal antibodies to cell surface markers of human exocrine pancreas were used to establish the cytotypic expression of cells forming “tubular complexes” in pancreases from six adults without carcinoma and in the nontumorous pancreatic parenchyma of 16 pancreases with carcinoma. These cells manifested duct cell determinants. In general, the presence of cells with duct cell surface markers within the acini corresponded to the normal distribution of centroacinar cells in the 30 control human pancreases (from cadaveric donors); however, foci of abnormal acini were seen in these pancreases independent of or intermingled with the “tubular complexes.” The acini in these abnormal areas were formed by a core of cells and cell processes that expressed duct cell determinants. They were partially surrounded by acinar cells and showed slight or no lumenal dilation. While the causative agent(s), the cell(s) of origin, and the regression and/or progression of these lesions are yet to be determined, the replacement of acini by the spectrum of lesions composed of cells with duct cell surface marker is suggested to constitute ductal metaplasia.

Footnotes

  • ↵1 This work was supported in part by Grant 5R01CA30354 from the National Cancer Institute and Grant 2R01CA22682 awarded through the National Pancreatic Cancer Project from the National Cancer Institute.

  • ↵2 To whom requests for reprints should be addressed.

  • Received April 11, 1984.
  • Accepted November 21, 1984.
  • ©1985 American Association for Cancer Research.
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March 1985
Volume 45, Issue 3
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Ductal Metaplasia of Human Exocrine Pancreas and Its Association with Carcinoma
Ismail Parsa, Daniel S. Longnecker, Dante G. Scarpelli, Parviz Pour, Janardan K. Reddy and Martin Lefkowitz
Cancer Res March 1 1985 (45) (3) 1285-1290;

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Ductal Metaplasia of Human Exocrine Pancreas and Its Association with Carcinoma
Ismail Parsa, Daniel S. Longnecker, Dante G. Scarpelli, Parviz Pour, Janardan K. Reddy and Martin Lefkowitz
Cancer Res March 1 1985 (45) (3) 1285-1290;
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