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Basic Sciences

Antineuroblastoma Activity of Desferoxamine in Human Cell Lines

Julie Blatt and Suzette Stitely
Julie Blatt
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Suzette Stitely
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DOI:  Published April 1987
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Abstract

That ferritin, an iron storage protein, can be produced by neuroblastoma cells raises the possibility that iron may have some role in promoting tumor cell growth. To explore this possibility, we studied the effects of desferoxamine, a compound which chelates iron, on viability of CHP 126 and CHP 100, two human neuroblastoma cell lines. Cells (5 × 104) were incubated with graded amounts of desferoxamine or ferrioxamine, an iron-saturated analogue of desferoxamine. Within 5 days of exposure to 60 µm desferoxamine, approximately 90% of cells from each of these cell lines were dead. This effect was dose dependent, was not seen with ferrioxamine, and could be prevented by coincubation with greater than stoichiometric amounts of ferric citrate. As determined by binding of OK-T9, desferoxamine also resulted in increased expression of receptors for transferrin, an iron transport protein. Desferoxamine had only minimal effects on viability of several non-neuroblastoma cell lines. These results suggest that iron is required for growth of neuroblastoma and that desferoxamine has potent, specific, antineuroblastoma activity in vitro.

Footnotes

  • ↵1 Supported by grants from the Human Rights Committee, Children's Hospital of Pittsburgh, and from the Health Research and Services Foundation (Grant AA-68).

  • ↵2 To whom requests for reprints should be addressed, at Children's Hospital of Pittsburgh, 125 DeSoto St., Pittsburgh, PA 15213.

  • Received May 5, 1986.
  • Revision received October 28, 1986.
  • Accepted December 29, 1986.
  • ©1987 American Association for Cancer Research.
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April 1987
Volume 47, Issue 7
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Antineuroblastoma Activity of Desferoxamine in Human Cell Lines
Julie Blatt and Suzette Stitely
Cancer Res April 1 1987 (47) (7) 1749-1750;

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Antineuroblastoma Activity of Desferoxamine in Human Cell Lines
Julie Blatt and Suzette Stitely
Cancer Res April 1 1987 (47) (7) 1749-1750;
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