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Basic Sciences

Inhibition of the Tumor-promoting Action of 12-O-Tetradecanoylphorbol-13-acetate by Some Oleanane-type Triterpenoid Compounds

Hoyoku Nishino, Atsuko Nishino, Junko Takayasu, Teiko Hasegawa, Akio Iwashima, Kazuhiro Hirabayashi, Susumu Iwata and Shoji Shibata
Hoyoku Nishino
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Atsuko Nishino
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Junko Takayasu
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Teiko Hasegawa
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Akio Iwashima
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Kazuhiro Hirabayashi
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Susumu Iwata
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Shoji Shibata
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DOI:  Published September 1988
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Abstract

Since glycyrrhetinic acid was proved to suppress tumor promoter effects, several oleanane-type triterpenes which were chemically derived from oleanolic acid and hederagenin were tested in vitro and in vivo against the action of tumor promoter, 12-O-tetradecanoylphorbol 13-acetate.

By in vitro experiment monitoring with 12 - O - tetradecanoylphorbol-13-acetate-induced stimulation of 32P1 incorporation into phospholipids and an in vivo test on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene and promoted with 12-O-tetradecanoylphorbol-13-acetate, 18β-olean-12-ene-3β,28-diol, (=erythrodiol), 18β-olean-12-ene-3β,23,28-triol, 18α-olean-12-ene-3β,28-diol, and 18α-olean-12-ene-3β,23,28-triol showed remarkable suppressive effects. Especially 18α-oleanane derivatives having a CH2OH grouping converted from the COOH group initially allocated at C-17 were 100 times more effective than glycyrrhetinic acid both in vitro and in vivo.

Footnotes

    • Received March 2, 1988.
    • Revision received June 17, 1988.
    • Accepted June 21, 1988.
    • ©1988 American Association for Cancer Research.
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    September 1988
    Volume 48, Issue 18
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    Inhibition of the Tumor-promoting Action of 12-O-Tetradecanoylphorbol-13-acetate by Some Oleanane-type Triterpenoid Compounds
    Hoyoku Nishino, Atsuko Nishino, Junko Takayasu, Teiko Hasegawa, Akio Iwashima, Kazuhiro Hirabayashi, Susumu Iwata and Shoji Shibata
    Cancer Res September 15 1988 (48) (18) 5210-5215;

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    Inhibition of the Tumor-promoting Action of 12-O-Tetradecanoylphorbol-13-acetate by Some Oleanane-type Triterpenoid Compounds
    Hoyoku Nishino, Atsuko Nishino, Junko Takayasu, Teiko Hasegawa, Akio Iwashima, Kazuhiro Hirabayashi, Susumu Iwata and Shoji Shibata
    Cancer Res September 15 1988 (48) (18) 5210-5215;
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