Table of Contents

Articles

• Perspectives in Cancer Research

  Reducing Avoidable Cancer Mortality through Prevention and Early Detection Regimens

  Caryn Lerman, Barbara Rimer and Paul F. Engstrom

  Cancer Res September 15 1989 49 (18) 4955-4962;

  
  
• Basic Sciences

  Inhibitory Effect of Antibody against Basic Fibroblast Growth Factor on Androgen- or Glucocorticoid-induced Growth of Shionogi Carcinoma 115 Cells in Serum-free Culture

  Jian Lu, Yasuko Nishizawa, Akira Tanaka, Norio Nonomura, Hiroshi Yamanishi, Naomi Uchida, Bunzo Sato and Keishi Matsumoto

  Cancer Res September 15 1989 49 (18) 4963-4967;

  
  
• Basic Sciences

  Differential Expression of the c-erbB-2 Gene in Human Small Cell and Non-Small Cell Lung Cancer

  Paul M. Schneider, Mien-Chie Hung, Susanna M. Chiocca, John Manning, Xiaoyan Zhao, Kang Fang and Jack A. Roth

  Cancer Res September 15 1989 49 (18) 4968-4971;

  
  
• Basic Sciences

  Biochemical Pharmacology of 2-Chlorodeoxyadenosine in Malignant Human Hematopoietic Cell Lines and Therapeutic Effects of 2-Bromodeoxyadenosine in Drug Combinations in Mice

  Thomas L. Avery, Jerold E. Rehg, Wendy C. Lumm, Franklin C. Harwood, Victor M. Santana and Raymond L. Blakley

  Cancer Res September 15 1989 49 (18) 4972-4978;

  
  
• Basic Sciences

  Adoptive Immunotherapy as an Adjunctive Treatment to Thoracic Irradiation for Pulmonary Tumor Deposits in Mice

  Luka Milas, Gregor Sersa, Veronica Willingham, Nancy Hunter and Shiao Woo

  Cancer Res September 15 1989 49 (18) 4979-4982;

  
  
• Basic Sciences

  Mechanism of Adenosine Triphosphate Catabolism Induced by Deoxyadenosine and by Nucleoside Analogues in Adenosine Deaminase-inhibited Human Erythrocytes

  Françoise Bontemps and Georges Van den Berghe

  Cancer Res September 15 1989 49 (18) 4983-4989;

  
  
• Basic Sciences

  Enhanced Therapeutic Efficacy of an Immunotoxin in Combination with Chemotherapy against an Intraperitoneal Human Tumor Xenograft in Athymic Mice

  John W. Pearson, Gowsala Sivam, Ron Manger, Robert H. Wiltrout, A. C. Morgan Jr. and Dan L. Longo

  Cancer Res September 15 1989 49 (18) 4990-4995;

  
  
• Basic Sciences

  Evidence for Enzymatic Activation and Oxygen Involvement in Cytotoxicity and Antitumor Activity of N,N′,N″-Triethylenethiophosphoramide

  Beverly A. Teicher, David J. Waxman, Sylvia A. Holden, Yenyun Wang, Lynn Clarke, Enrique Alvarez Sotomayor, Steven M. Jones and Emil Frei III

  Cancer Res September 15 1989 49 (18) 4996-5001;

  
  
• Basic Sciences

  Reversal Mechanism of Multidrug Resistance by Verapamil: Direct Binding of Verapamil to P-Glycoprotein on Specific Sites and Transport of Verapamil Outward across the Plasma Membrane of K562/ADM Cells

  Keisuke Yusa and Takashi Tsuruo

  Cancer Res September 15 1989 49 (18) 5002-5006;

  
  
• Basic Sciences

  Lysis of Antigenically Unrelated Tumor Cells Mediated by Lyt 2⁺ Splenic T-Cells from Melphalan-cured MOPC-315 Tumor Bearers

  Edward Barker, James A. Wise, Sheldon Dray and Margalit B. Mokyr

  Cancer Res September 15 1989 49 (18) 5007-5015;

  
  
• Basic Sciences

  Protein-linked DNA Strand Breaks Induced in Mammalian Cells by Camptothecin, an Inhibitor of Topoisomerase I

  Joseph M. Covey, Christine Jaxel, Kurt W. Kohn and Yves Pommier

  Cancer Res September 15 1989 49 (18) 5016-5022;

  
  
• Basic Sciences

  Metabolism and Murine Pharmacokinetics of the 8-(N,N-Dimethylcarboxamide) Analogue of the Experimental Antitumor Drug Mitozolomide (NSC353451)

  Keith R. Horspool, Charmaine P. Quarterman, John A. Slack, Andreas Gescher, Malcolm F. G. Stevens and Edward Lunt

  Cancer Res September 15 1989 49 (18) 5023-5026;

  
  
• Basic Sciences

  Influence of Cellular, Microenvironmental, and Growth Parameters on Thermotolerance Kinetics in Vivo in Human Melanoma Xenografts

  Einar K. Rofstad

  Cancer Res September 15 1989 49 (18) 5027-5032;

  
  
• Basic Sciences

  Expression of Messenger RNA Species Coding for a M_r 43,000 Peptide Associated with Ferritin in Human Leukemia-K562 Cells and Its Down Regulation during Differentiation

  Nava Shterman, Batia Kupfer and Chaya Moroz

  Cancer Res September 15 1989 49 (18) 5033-5036;

  
  
• Basic Sciences

  Induction of Human Monocyte Susceptibility to Lymphokine-activated Killer Cell Lysis by Granulocyte-Macrophage Colony-stimulating Factor

  D. Kay Blanchard, Debbie Serbousek and Julie Y. Djeu

  Cancer Res September 15 1989 49 (18) 5037-5043;

  
  
• Basic Sciences

  Genetic Variation in Liver Tumor Susceptibility, Plasma Testosterone Levels, and Androgen Receptor Binding in Six Inbred Strains of Mice

  Christopher J. Kemp and Norman R. Drinkwater

  Cancer Res September 15 1989 49 (18) 5044-5047;

  
  
• Basic Sciences

  Mechanism of Transport and Intracellular Binding of Porfiromycin in HCT 116 Human Colon Carcinoma Cells

  Su-shu Pan, Robin Johnson, Hector Gonzalez and Vinay Thohan

  Cancer Res September 15 1989 49 (18) 5048-5053;

  
  
• Basic Sciences

  Association among DNA/Chromosome Break Rejoining Rates, Chromatin Structure Alterations, and Radiation Sensitivity in Human Cell Lines

  Jeffrey L. Schwartz and Andrew T. M. Vaughan

  Cancer Res September 15 1989 49 (18) 5054-5057;

  
  
• Basic Sciences

  Immunological and Pharmacological Removal of Small Cell Lung Cancer Cells from Bone Marrow Autografts

  Y. Humblet, A-M. Feyens, M. Sekhavat, D. Agaliotis, J-L. Canon and M. L. Symann

  Cancer Res September 15 1989 49 (18) 5058-5061;

  
  
• Basic Sciences

  Expression of a Human Multidrug Resistance Gene in Ovarian Carcinomas

  Jean Bourhis, Lori J. Goldstein, Guy Riou, Ira Pastan, Michael M. Gottesman and Jean Bénard

  Cancer Res September 15 1989 49 (18) 5062-5065;

  
  
• Basic Sciences

  Effects of Irradiation on the Release of Growth Factors from Cultured Bovine, Porcine, and Human Endothelial Cells

  Larry Witte, Zvi Fuks, Adriana Haimovitz-Friedman, Israel Vlodavsky, DeWitt S. Goodman and Amiram Eldor

  Cancer Res September 15 1989 49 (18) 5066-5072;

  
  
• Basic Sciences

  Role of Ornithine Decarboxylase in Diallyl Sulfide Inhibition of Colonic Radiation Injury in the Mouse

  Allan R. Baer and Michael J. Wargovich

  Cancer Res September 15 1989 49 (18) 5073-5076;

  
  
• Basic Sciences

  Arrest of Replication Forks by Drug-stabilized Topoisomerase I-DNA Cleavable Complexes as a Mechanism of Cell Killing by Camptothecin

  Yaw-Huei Hsiang, Michelle G. Lihou and Leroy F. Liu

  Cancer Res September 15 1989 49 (18) 5077-5082;

  
  
• Basic Sciences

  The Effect of Vitamin D₃ on the Production of Cytotoxic Factors by Human Peripheral Blood Mononuclear Cells

  Shookooh Yousefi, Dinh Vu, Gloria Carandang, Robert Yamamoto, Gale Granger, N. Vaziri, J. Ocariz and Thomas Cesario

  Cancer Res September 15 1989 49 (18) 5083-5086;

  
  
• Basic Sciences

  Regional Loss of Chromosome 6 in Two Urological Malignancies

  Daniel B. Rukstalis, Glenn J. Bubley, John P. Donahue, Jerome P. Richie, J. G. Seidman and William C. DeWolf

  Cancer Res September 15 1989 49 (18) 5087-5090;

  
  
• Basic Sciences

  Antigenic Profile of Tumor Progression Stages in Human Melanocytic Nevi and Melanomas

  David E. Elder, Ulrich Rodeck, Jan Thurin, Francis Cardillo, Wallace H. Clark, Rosemary Stewart and Meenhard Herlyn

  Cancer Res September 15 1989 49 (18) 5091-5096;

  
  
• Basic Sciences

  Therapy of Central Nervous System Leukemia in Mice by Liposome-entrapped 1-β-d-Arabinofuranosylcytosine

  Feng Hong and Eric Mayhew

  Cancer Res September 15 1989 49 (18) 5097-5102;

  
  
• Basic Sciences

  Controlled Delivery of 1,3-Bis(2-chloroethyl)-1-nitrosourea from Ethylene-Vinyl Acetate Copolymer

  Michael B. Yang, Rafael J. Tamargo and Henry Brem

  Cancer Res September 15 1989 49 (18) 5103-5107;

  
  
• Basic Sciences

  Comparison of the Mechanism of Action of Busulfan with Hepsulfam, a New Antileukemic Agent, in the L1210 Cell Line

  Diane Y. Pacheco, Nancy K. Stratton and Neil W. Gibson

  Cancer Res September 15 1989 49 (18) 5108-5110;

  
  
• Basic Sciences

  Inhibitory Effects of the Tyrosine Kinase Inhibitor Genistein on Mammalian DNA Topoisomerase II

  Judith Markovits, Claude Linassier, Philippe Fossé, Jeanine Couprie, Josiane Pierre, Alain Jacquemin-Sablon, Jean-Marie Saucier, Jean-Bernard Le Pecq and Annette K. Larsen

  Cancer Res September 15 1989 49 (18) 5111-5117;

  
  
• Basic Sciences

  Lung Cancer-associated Monoclonal Antibody 15 That Recognizes Cell Growth-related Membrane Antigens gp85/45 and Its Growth-inhibitory Effect on Human Lung Cancer Cells in Vitro

  Hiroshi Kamma, Katsuyuki Endo, Hisashi Horiguchi, Tatsuo Iijima and Takesaburo Ogata

  Cancer Res September 15 1989 49 (18) 5118-5122;

  
  
• Basic Sciences

  Effect of Doxorubicin on Mouse Hybridoma B Cells: Stimulation of Immunoglobulin Synthesis and Secretion

  Jean-Luc Teillaud, Alain Fourcade, Joseph Huppert, Wolf H. Fridman and Haim Tapiero

  Cancer Res September 15 1989 49 (18) 5123-5129;

  
  
• Basic Sciences

  Concordant Deletions of Chromosome 3p and Loss of Heterozygosity for Chromosomes 13 and 17 in Small Cell Lung Carcinoma

  Naoki Mori, Jun Yokota, Mitsuo Oshimura, Webster K. Cavenee, Hideaki Mizoguchi, Masayuki Noguchi, Yukio Shimosato, Takashi Sugimura and Masaaki Terada

  Cancer Res September 15 1989 49 (18) 5130-5135;

  
  
• Basic Sciences

  Autocrine Growth Factor in Defined Serum-free Medium of Human Salivary Gland Adenocarcinoma Cell Line HSG

  Riki Kurokawa, Seiko Kyakumoto and Minoru Ota

  Cancer Res September 15 1989 49 (18) 5136-5142;

  
  
• Basic Sciences

  Promotion by Dihydroxybenzene Derivatives of N-Methyl-N′-nitro-N-nitrosoguanidine-induced F344 Rat Forestomach and Glandular Stomach Carcinogenesis

  Masao Hirose, Shuji Yamaguchi, Shoji Fukushima, Ryohei Hasegawa, Satoshi Takahashi and Nobuyuki Ito

  Cancer Res September 15 1989 49 (18) 5143-5147;

  
  
• Basic Sciences

  A Human Tumor Lung Metastasis Model in Athymic Nude Rats

  Inge Kjønniksen, Ritsa Storeng, Alexander Pihl, Theodore L. McLemore and Øystein Fodstad

  Cancer Res September 15 1989 49 (18) 5148-5152;

  
  
• Basic Sciences

  Establishment and Characterization of a Human Ovarian Neoplastic Cell Line, DO-s

  Tony W. Briers, Patricia Stroobants, Tanja M. Vandeputte, Etienne J. Nouwen, M. Viviane Conraads, Gerard Eestermans, D. Van Bockstaele and Marc. E. De Broe

  Cancer Res September 15 1989 49 (18) 5153-5161;

  
  
• Basic Sciences

  Detection of an Intrinsic Marker in Hypoxic Cells

  Lynn Hlatky, Christine S. Ring and Rainer K. Sachs

  Cancer Res September 15 1989 49 (18) 5162-5166;

  
  
• Basic Sciences

  Biology, Cytogenetics, and Sensitivity to Immunological Effector Cells of New Head and Neck Squamous Cell Carcinoma Lines

  D. S. Heo, C. Snyderman, S. M. Gollin, S. Pan, E. Walker, R. Deka, E. L. Barnes, J. T. Johnson, R. B. Herberman and T. L. Whiteside

  Cancer Res September 15 1989 49 (18) 5167-5175;

  
  
• Basic Sciences

  Comparison of an Immunocytochemical Assay for Progesterone Receptor with a Biochemical Method of Measurement and Immunocytochemical Examination of the Relationship between Progesterone and Estrogen Receptors

  Uta Berger, Pat Wilson, Suki Thethi, Richard A. McClelland, Geoffrey L. Greene and R. Charles Coombes

  Cancer Res September 15 1989 49 (18) 5176-5179;

  
  
• Basic Sciences

  Role of 2′-5′-Oligoadenylate Synthetase in γ-Interferon-mediated Growth Inhibition of A431 Cells

  Rakesh Kumar and John Mendelsohn

  Cancer Res September 15 1989 49 (18) 5180-5184;

  
  
• Basic Sciences

  Association of Low nm23 RNA Levels in Human Primary Infiltrating Ductal Breast Carcinomas with Lymph Node Involvement and Other Histopathological Indicators of High Metastatic Potential

  Generoso Bevilacqua, Mark E. Sobel, Lance A. Liotta and Patricia S. Steeg

  Cancer Res September 15 1989 49 (18) 5185-5190;

  
  
• Basic Sciences

  Altered Function of Protein Kinase C and Cyclic Adenosine Monophosphate-dependent Protein Kinase in a Cell Line Derived from a Mouse Lung Papillary Tumor

  Kendal M. Nicks, Kurt A. Droms, Tellef Fossli, Garry J. Smith and Alvin M. Malkinson

  Cancer Res September 15 1989 49 (18) 5191-5198;

  
  
• Basic Sciences

  Loss of Calcitonin Receptors: A Genetically Transmitted Defect in Rats with High Incidence of C-Cell Tumors

  Z. Bouizar, S. Minvielle, F. Treilhou-Lahille, W. H. Rostene, E. Pidoux, N. Feingold, G. Milhaud and M. S. Moukhtar

  Cancer Res September 15 1989 49 (18) 5199-5202;

  
  
• Clinical and Epidemiological Investigations

  Breast Cancer and Alcohol Consumption: A Case-Control Study in Northern Italy

  Paolo Toniolo, Elio Riboli, Fulvia Protta, Martine Charrel and Alberto P. M. Cappa

  Cancer Res September 15 1989 49 (18) 5203-5206;

  
  
• Clinical and Epidemiological Investigations

  Biological Amplification Factor for Sunlight-induced Nonmelanoma Skin Cancer at High Latitudes

  Johan Moan, Arne Dahlback, Thormod Henriksen and Knut Magnus

  Cancer Res September 15 1989 49 (18) 5207-5212;

  
  
• Clinical and Epidemiological Investigations

  Phase I Trial and Pharmacokinetic Evaluation of Fazarabine in Children

  Richard L. Heideman, Andrea Gillespie, Harry Ford, Gregory H. Reaman, Frank M. Balis, Charlotte Tan, Judy Sato, Lawrence J. Ettinger, Roger J. Packer and David G. Poplack

  Cancer Res September 15 1989 49 (18) 5213-5216;

  
  
• Clinical and Epidemiological Investigations

  Phase I Clinical Study of N-[(4-Chlorophenyl)amino]carbonyl-2,3-dihydro-1H-indene-5-sulfonamide (LY186641)

  John D. Hainsworth, Kenneth R. Hande, Winston G. Satterlee, John Kuttesch, David H. Johnson, Gerald Grindey, Linda E. Jackson and F. Anthony Greco

  Cancer Res September 15 1989 49 (18) 5217-5220;

  
  
• Clinical and Epidemiological Investigations

  Dose Escalation Study of Recombinant Human Granulocyte-Colony-stimulating Factor (KRN8601) in Patients with Advanced Malignancy

  Kenji Eguchi, Satoru Sasaki, Tomohide Tamura, Yasutsuna Sasaki, Tetsu Shinkai, Kouzou Yamada, Yoshifumi Soejima, Masaaki Fukuda, Yasuhiro Fujihara, Hideo Kunitou, Kensei Tobinai, Tomoko Ohtsu, Keiichi Suemasu, Fumimaro Takaku and Nagahiro Saijo

  Cancer Res September 15 1989 49 (18) 5221-5224;

  
  
• Clinical and Epidemiological Investigations

  Elevation of the Placental Glutathione S-Transferase Form (GST-π) in Tumor Tissues and the Levels in Sera of Patients with Cancer

  Shigeki Tsuchida, Yoshihito Sekine, Ryuzaburo Shineha, Tetsuro Nishihira and Kiyomi Sato

  Cancer Res September 15 1989 49 (18) 5225-5229;

  
  
• Clinical and Epidemiological Investigations

  Differences between in Vivo and in Vitro Activation of Cancer Patient Lymphocytes by Recombinant Interleukin 2: Possible Role for Lymphokine-activated Killer Cell Infusion in the in Vivo-induced Activation

  Carlo Gambacorti-Passerini, Licia Rivoltini, Marina Radrizzani, Filiberto Belli, Gianalfredo Sciorelli, Fernando Ravagnani, Andrew R. Galazka, Natale Cascinelli and Giorgio Parmiani

  Cancer Res September 15 1989 49 (18) 5230-5234;

  
  
• Articles

  Announcements

  Cancer Res September 15 1989 49 (18) 5235-5236;

  
  
• Erratum

  Human Monoclonal Antibodies to Glycolipids and Other Carbohydrate Antigens: Dissection of the Humoral Immune Response in Cancer Patients

  Cancer Res September 15 1989 49 (18) 5236-5236;

  
  
• Erratum

  Experimental Therapy of Human Breast Tumors with ¹³¹I-labeled Monoclonal Antibodies Prepared against the Human Milk Fat Globule

  Cancer Res September 15 1989 49 (18) 5236-5236;

  
  
• Erratum

  Reversible Suppression of c-myc Expression in a Human Colon Carcinoma Line by the Anticancer Agent N-Methylformamide

  Cancer Res September 15 1989 49 (18) 5236-5236;