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Basic Sciences

Differential Expression of the c-erbB-2 Gene in Human Small Cell and Non-Small Cell Lung Cancer

Paul M. Schneider, Mien-Chie Hung, Susanna M. Chiocca, John Manning, Xiaoyan Zhao, Kang Fang and Jack A. Roth
Paul M. Schneider
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Mien-Chie Hung
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Susanna M. Chiocca
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John Manning
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Xiaoyan Zhao
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Kang Fang
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Jack A. Roth
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DOI:  Published September 1989
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Abstract

We studied non-small cell lung cancers (NSCLC) from 60 patients for abnormalities in the c-erbB-2 gene. Eleven human lung cancer cell lines, including four derived from small cell lung cancer (SCLC) and seven derived from NSCLC were also examined for altered c-erbB-2 gene expression. Southern blot analysis of paired tumor and normal lung samples demonstrated that amplification of the c-erbB-2 gene is rare in NSCLC (2/60) and not restricted to adenocarcinomas. One patient showed an EcoRI restriction fragment length polymorphism for the c-erbB-2 locus. Four of four SCLC cell lines demonstrated minimal or nondetectable expression of c-erbB-2 mRNA compared to high levels of expression by seven of seven NSCLC lines. The highest expression levels were seen in four of four adenocarcinomas. We conclude that c-erbB-2 expression is different in SCLC compared to NSCLC and high expression of c-erbB-2 is consistently present in lung adenocarcinomas.

Footnotes

  • ↵2 Supported by NCI Grant CA45187-01.

  • ↵3 Supported by Grants NCI CA45265-01 and ACS-CD-360, NIH Grants RR5511-23, and the Basil O'Connor Starter Scholar Research Award 5-621 from the March of Dimes Foundation.

  • ↵4 Recipient of a Rosalie B. Hite Graduate Fellowship.

  • ↵5 To whom requests for reprints should be addressed, at Department of Thoracic Surgery, Box 109, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030.

  • Received March 1, 1989.
  • Revision received June 5, 1989.
  • Accepted June 16, 1989.
  • ©1989 American Association for Cancer Research.
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September 1989
Volume 49, Issue 18
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Differential Expression of the c-erbB-2 Gene in Human Small Cell and Non-Small Cell Lung Cancer
Paul M. Schneider, Mien-Chie Hung, Susanna M. Chiocca, John Manning, Xiaoyan Zhao, Kang Fang and Jack A. Roth
Cancer Res September 15 1989 (49) (18) 4968-4971;

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Differential Expression of the c-erbB-2 Gene in Human Small Cell and Non-Small Cell Lung Cancer
Paul M. Schneider, Mien-Chie Hung, Susanna M. Chiocca, John Manning, Xiaoyan Zhao, Kang Fang and Jack A. Roth
Cancer Res September 15 1989 (49) (18) 4968-4971;
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