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Basic Sciences

Promotion by Dihydroxybenzene Derivatives of N-Methyl-N′-nitro-N-nitrosoguanidine-induced F344 Rat Forestomach and Glandular Stomach Carcinogenesis

Masao Hirose, Shuji Yamaguchi, Shoji Fukushima, Ryohei Hasegawa, Satoshi Takahashi and Nobuyuki Ito
Masao Hirose
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Shuji Yamaguchi
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Shoji Fukushima
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Ryohei Hasegawa
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Satoshi Takahashi
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Nobuyuki Ito
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DOI:  Published September 1989
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Abstract

Modifying effects of resorcinol, hydroquinone, p-tert-butylcatechol (PTBC), p-methylcatechol (PMC), and o-methylcatechol on N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced forestomach and glandular stomach carcinogenesis were investigated in F344 rats. Groups of 15 to 16 male 6-wk-old animals were given a single intragastric administration of 150 mg/kg of body weight of MNNG and starting 1 wk later were administered powdered diet containing 0.8% resorcinol, 0.8% hydroquinone, 1.5% PTBC, 1.5% o-methylcatechol, 1.5% PMC, or basal diet alone for 51 wk. Additional groups of 10 to 15 rats each were treated with the phenolic compounds or received basal diet without prior carcinogen exposure. Histological examination after sacrifice at Wk 52 revealed that squamous cell carcinoma development in the forestomachs of rats treated with MNNG followed by PTBC (75%, P < 0.001) or MNNG followed by PMC (100%, P < 0.001) was significantly greater than in animals receiving MNNG alone (20%). Treatment with PMC alone also resulted in a 40% yield of papilloma. In the glandular stomach, incidences of adenomatous hyperplasias in rats treated with MNNG followed by PTBC (31.3%, P < 0.05) or PMC (100%, P < 0.001) and the incidence of adenocarcinomas in rats treated with MNNG followed by PMC (100%, P < 0.001) were significantly higher than in controls. In addition, PMC alone induced a 100% yield of adenomatous hyperplasias and 6.7% of adenocarcinomas. Thus, the results demonstrated that PTBC and PMC treatment significantly enhances forestomach and glandular stomach carcinogenesis and that PMC itself may possess weak carcinogenic potential in these organs. The ortho-position appears to be important for this dihydroxybenzene activity.

Footnotes

  • ↵1 This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science, and Culture and a grant from the Ministry of Health and Welfare of Japan.

  • ↵2 To whom requests for reprints should be addressed, at the First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuhocho, Mizuho-ku, Nagoya 467, Japan.

  • Received February 1, 1989.
  • Revision received May 26, 1989.
  • Accepted June 15, 1989.
  • ©1989 American Association for Cancer Research.
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September 1989
Volume 49, Issue 18
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Promotion by Dihydroxybenzene Derivatives of N-Methyl-N′-nitro-N-nitrosoguanidine-induced F344 Rat Forestomach and Glandular Stomach Carcinogenesis
Masao Hirose, Shuji Yamaguchi, Shoji Fukushima, Ryohei Hasegawa, Satoshi Takahashi and Nobuyuki Ito
Cancer Res September 15 1989 (49) (18) 5143-5147;

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Promotion by Dihydroxybenzene Derivatives of N-Methyl-N′-nitro-N-nitrosoguanidine-induced F344 Rat Forestomach and Glandular Stomach Carcinogenesis
Masao Hirose, Shuji Yamaguchi, Shoji Fukushima, Ryohei Hasegawa, Satoshi Takahashi and Nobuyuki Ito
Cancer Res September 15 1989 (49) (18) 5143-5147;
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